Results 31 to 40 of about 18,473 (221)

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Neurobiology of Disease, 2015
The accumulation of DNA and RNA oxidative damage is observed in cortical and hippocampal neurons from Alzheimer's disease (AD) brains at early stages of pathology.
Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Galas   +13 more
doaj   +1 more source

Tau-dependent HDAC1 nuclear reduction is associated with altered VGluT1 expression

Frontiers in Cell and Developmental Biology, 2023
During AD pathology, Tau protein levels progressively increase from early pathological stages. Tau altered expression causes an unbalance of Tau subcellular localization in the cytosol and in the nuclear compartment leading to synaptic dysfunction ...
Giacomo Siano, Giuseppe Madaro, Giuseppe Madaro, Maria Claudia Caiazza, Maria Claudia Caiazza, Awatef Allouch, Martina Varisco, Marianna Mignanelli, Antonino Cattaneo, Antonino Cattaneo, Cristina Di Primio   +10 more
doaj   +1 more source

Passive tau-based immunotherapy for tauopathies

, 2023
: Tauopathies are heterogeneous clinicopathological entities characterized by abnormal neuronal and/or glial inclusions of the microtubule-binding protein tau.
Daniele, Antonio
core   +1 more source

Impact of Tau on Neurovascular Pathology in Alzheimer's Disease

Frontiers in Neurology, 2021
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most prevalent cause of dementia. The main cerebral histological hallmarks are represented by parenchymal insoluble deposits of amyloid beta (Aβ plaques) and neurofibrillary tangles
Elisa Canepa, Silvia Fossati
doaj   +1 more source

Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies [PDF]

Purpose We hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more severe striatal dopamine deficiency in four-repeat (4R) tauopathies.
Rumpf, Jost-Julian, Classen, Joseph, Finze, A., Palleis, Carla, Palleis, C., Franzmeier, Nicolai, Wall, S., Ferschmann, C., Stephens, Andrew, Schildan, A., Ferschmann, Christian, Sabri, O., Scheifele, M., Wall, Stephan, Sabri, Osama, Schroeter, Matthias L., Höglinger, G., Patt, Marianne, Marek, K., Levin, Johannes, Katzdobler, S., Eckenweber, Florian, Gnörich, Johannes, Beyer, Leonie, Hoeglinger, Guenter U., Fietzek, Urban, Bartenstein, P., Seibyl, J., Saur, Dorothee, Barthel, Henryk, Höglinger, Günter U., Messerschmidt, Konstantin, Fietzek, U., Gnoerich, Johannes, Patt, M., Stockbauer, Anna, Classen, J., Seibyl, John, Schildan, Andreas, Rumpf, J., Saur, D., Rullmann, M., Scheifele, Maximilian, Barthel, H., Franzmeier, N., Finze, Anika, Biechele, Gloria, Rullmann, Michael, Messerschmidt, K., Katzdobler, Sabrina, Brendel, Matthias, Levin, J., for the German Imaging Initiative for Tauopathies (GII4T), Stockbauer, A., Marek, Ken, Gnörich, J., Beyer, L., Schroeter, M. ; https://orcid.org/, Brendel, M., Eckenweber, F., Stephens, A., Bartenstein, Peter, Biechele, G.   +62 more
core   +1 more source

Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity

Frontiers in Aging Neuroscience, 2021
Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules.
Luciana Medina, Florencia González-Lizárraga, Antonio Dominguez-Meijide, Antonio Dominguez-Meijide, Antonio Dominguez-Meijide, Diego Ploper, Valeria Parrales, Sabrina Sequeira, Maria-Sol Cima-Omori, Markus Zweckstetter, Markus Zweckstetter, Elaine Del Bel, Patrick P. Michel, Tiago Fleming Outeiro, Tiago Fleming Outeiro, Tiago Fleming Outeiro, Rita Raisman-Vozari, Rosana Chehín, Sergio B. Socias   +18 more
doaj   +1 more source

Glial Tau Pathology in Tauopathies: Functional Consequences

, 2015
Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells.
Martha A. Kahlson, Kenneth J. Colodner
core   +1 more source

Transgenic animal models of tauopathies [PDF]

, 2004
Tauopathies are a group of neurodegenerative disorders that include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases with prominent tau pathology.
Kenyon, Theresa K., Theresa K. Kenyon, Lee, Virginia M.-Y., Trojanowski, John Q., John Q. Trojanowski, Virginia M.-Y. Lee   +5 more
core   +1 more source

An unusual presentation of Huntington’s disease

Clinical Case Reports, 2021
We describe the case of a 59‐year‐old woman who exhibited psychotic symptoms, cognitive dysfunction, and restlessness. While the clinical picture and 18F‐FDG PET/CT suggested the presence of a tauopathy, especially frontotemporal dementia or progressive ...
Martin Schulze Westhoff, Alma Osmanovic, Catharina Meissner, Johannes Heck, Nima Mahmoudi, Corinna Hendrich, Georg Berding, Johanna Seifert, Stefan Bleich, Helge Frieling, Tillmann Krüger, Adrian Groh   +11 more
doaj   +1 more source

Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice

Cells, 2020
Tau dysfunction is common in several neurodegenerative diseases including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Affective symptoms have often been associated with aberrant tau pathology and are commonly comorbid in patients ...
Marangelie Criado-Marrero, Jonathan J. Sabbagh, Margaret R. Jones, Dale Chaput, Chad A. Dickey, Laura J. Blair   +5 more
doaj   +1 more source