Results 11 to 20 of about 1,190 (173)
Cellular and pathological heterogeneity of primary tauopathies
Molecular Neurodegeneration, 2021 Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies.
Dah-eun Chloe Chung +3 more
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Different tau species lead to heterogeneous tau pathology propagation and misfolding
Acta Neuropathologica Communications, 2018 Tauopathies are a heterogeneous group of pathologies characterized by tau aggregation inside neurons. Most of them are sporadic but certain tauopathies rely on tau gene (MAPT) mutations.
Simon Dujardin +13 more
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Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
Biomedical Journal, 2018 Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD or related dementia.
Cyril Laurent, Luc Buée, David Blum
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Tau deposition patterns are associated with functional connectivity in primary tauopathies
Nature Communications, 2022 Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
Nicolai Franzmeier +59 more
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Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. [PDF]
PLoS ONE, 2018 Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau.
Cara L Croft +6 more
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, 2012 Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules.
Gloria, Lee, Chad J, Leugers
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Critical Molecular and Cellular Contributors to Tau Pathology
Biomedicines, 2021 Tauopathies represent a group of neurodegenerative diseases including Alzheimer’s disease (AD) that are characterized by the deposition of filamentous tau aggregates in the brain.
Liqing Song +2 more
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Tauopathy and Movement Disorders—Unveiling the Chameleons and Mimics
Frontiers in Neurology, 2020 The spectrum of tauopathy encompasses heterogenous group of neurodegenerative disorders characterized by neural or glial deposition of pathological protein tau. Clinically they can present as cognitive syndromes, movement disorders, motor neuron disease,
Jacky Ganguly, Mandar Jog
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Brain Research Bulletin, 2016 Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valuable tools for neuropathological ...
Thomas, Arendt +2 more
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Chronic Traumatic Encephalopathy in Sports Practice: A Literature Review
Brazilian Neurosurgery, 2022 Chronic traumatic encephalopathy (CTE) is a neurodegenerative syndrome caused by repetitive and cumulative head trauma. Due to the widespread practice of contact and collision sports, a discussion of the long-term repercussions of repeated head trauma is
Luiz Henrique Salamoni Abad +8 more
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