Results 11 to 20 of about 13,185 (147)
Different tau species lead to heterogeneous tau pathology propagation and misfolding
Acta Neuropathologica Communications, 2018 Tauopathies are a heterogeneous group of pathologies characterized by tau aggregation inside neurons. Most of them are sporadic but certain tauopathies rely on tau gene (MAPT) mutations.
Simon Dujardin +13 more
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Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
Biomedical Journal, 2018 Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD or related dementia.
Cyril Laurent, Luc Buée, David Blum
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Tau deposition patterns are associated with functional connectivity in primary tauopathies
Nature Communications, 2022 Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
Nicolai Franzmeier +59 more
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Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. [PDF]
PLoS ONE, 2018 Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau.
Cara L Croft +6 more
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Critical Molecular and Cellular Contributors to Tau Pathology
Biomedicines, 2021 Tauopathies represent a group of neurodegenerative diseases including Alzheimer’s disease (AD) that are characterized by the deposition of filamentous tau aggregates in the brain.
Liqing Song +2 more
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Tauopathy and Movement Disorders—Unveiling the Chameleons and Mimics
Frontiers in Neurology, 2020 The spectrum of tauopathy encompasses heterogenous group of neurodegenerative disorders characterized by neural or glial deposition of pathological protein tau. Clinically they can present as cognitive syndromes, movement disorders, motor neuron disease,
Jacky Ganguly, Mandar Jog
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Frontiers in Molecular Neuroscience, 2023 Many preclinical and clinical studies support the use of antisense oligonucleotides (ASOs) as effective therapeutic strategies. However, acquiring ASOs for research purposes may be limited by partnerships with the pharmaceutical companies.
Pranav Vemula +2 more
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Neurobiology of Disease, 2015 The accumulation of DNA and RNA oxidative damage is observed in cortical and hippocampal neurons from Alzheimer's disease (AD) brains at early stages of pathology.
Marie Violet +13 more
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Frontiers in Neurology, 2020 Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and
Matthew J. Reid +4 more
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Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy
Antioxidants, 2022 Tauopathies such as Alzheimer’s disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer’s patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases in microglia,
José A. Fernández-Albarral +12 more
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