Results 11 to 20 of about 18,473 (221)
Molecular Pathogenesis of the Tauopathies
Annual Review of Pathology: Mechanisms of Disease, 2019 The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia as their common denominator. In this review, we describe the biochemical and histological differences in Tau pathology that are characteristic of the spectrum of frontotemporal lobar degeneration as primary tauopathies and of Alzheimer's disease as a secondary ...
Götz, Jürgen +2 more
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Spatial patterns of the tau-immunoreactive inclusions in eight different tauopathies are consistent with the spread of pathogenic tau [PDF]
, 2018 Introduction: The tauopathies are a major group of neurodegenerative disorders characterised by the presence of tau-immunoreactive inclusions in the cytoplasm of neurons and glia.
Armstrong, Richard A
core +8 more sources
Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies [PDF]
npj Parkinson's DiseaseMost neurodegenerative diseases lack definitive diagnostic tests, and the identification of easily accessible and reliable biomarkers remains a critical unmet need.
Ilaria Linda Dellarole +19 more
doaj +3 more sources
Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies [PDF]
Biology of Sex DifferencesBackground Four-repeat (4R)-tauopathies cause variable clinical profiles leading to clinical misdiagnosis. While sex differences are reported in Alzheimer’s disease (AD), Lewy body disease (LBD), and clinically-defined frontotemporal dementia (FTD ...
Ece Bayram +4 more
doaj +2 more sources
Early-Life Environment Influence on Late-Onset Alzheimer’s Disease
Frontiers in Cell and Developmental Biology, 2022 With the expand of the population’s average age, the incidence of neurodegenerative disorders has dramatically increased over the last decades. Alzheimer disease (AD) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily ...
Thibaut Gauvrit +9 more
doaj +1 more source
Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model
Frontiers in Molecular Neuroscience, 2022 Alzheimer’s disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glucose ...
Hamza Benderradji +42 more
doaj +1 more source
Immunotherapy for Tauopathies [PDF]
Journal of Molecular Neuroscience, 2011 Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach.
Jiaping, Gu, Einar M, Sigurdsson
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Tauopathies: new perspectives and challenges
Molecular Neurodegeneration, 2022 Background Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders ...
Yi Zhang +4 more
doaj +1 more source
Seminars in Neurology, 2019 Tauopathies are rare neurodegenerative disorders related to microtubule-associated protein tau, which functions to stabilize microtubules. Pathological changes caused by overexpression or hyperphosphorylation of tau lead to the disengagement of tau from microtubules and accumulation of toxic intracellular inclusions.
Farwa, Ali, Keith, Josephs
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Tau Stabilizes Chromatin Compaction
Frontiers in Cell and Developmental Biology, 2021 An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes remains elusive.
Thomas Rico +11 more
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