Results 21 to 30 of about 1,190 (173)

Astrogliopathy in Tauopathies [PDF]

Neuroglia, 2018
Astrocytes are involved in many diseases of the central nervous system, not only as reactive cells to neuronal damage but also as primary actors in the pathological process. Astrogliopathy is a term used to designate the involvement of astrocytes as key elements in the pathogenesis and pathology of diseases and injuries of the central nervous system ...
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Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Neurobiology of Disease, 2015
The accumulation of DNA and RNA oxidative damage is observed in cortical and hippocampal neurons from Alzheimer's disease (AD) brains at early stages of pathology.
Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Galas   +13 more
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Tau-dependent HDAC1 nuclear reduction is associated with altered VGluT1 expression

Frontiers in Cell and Developmental Biology, 2023
During AD pathology, Tau protein levels progressively increase from early pathological stages. Tau altered expression causes an unbalance of Tau subcellular localization in the cytosol and in the nuclear compartment leading to synaptic dysfunction ...
Giacomo Siano, Giuseppe Madaro, Giuseppe Madaro, Maria Claudia Caiazza, Maria Claudia Caiazza, Awatef Allouch, Martina Varisco, Marianna Mignanelli, Antonino Cattaneo, Antonino Cattaneo, Cristina Di Primio   +10 more
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Primary retinal tauopathy: A tauopathy with a distinct molecular pattern

Alzheimer's & Dementia, 2023
AbstractBACKGROUNDPhosphorylated tau (p‐tau) accumulation, a hallmark of Alzheimer's disease (AD), can also be found in the retina. However, it is uncertain whether it is linked to AD or another tauopathy.METHODSRetinas from 164 individuals, with and without AD, were analyzed for p‐tau accumulation and its relationship with age, dementia, and vision ...
Walkiewicz, Grzegorz, Ronisz, Alicja, Van Ginderdeuren, Rita, Lemmens, Sophie, Bouwman, Femke H., Hoozemans, Jeroen J.M., Morrema, Tjado H.J., Rozemuller, Annemieke J., Hart de Ruyter, Frederique J., De Groef, Lies, Stalmans, Ingeborg, Thal, Dietmar Rudolf   +11 more
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Pneumonia initiates a tauopathy [PDF]

The FASEB Journal, 2021
Abstract Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment
Ron Balczon, Mike T. Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B. Voth, Chun Zhou, Anna Koloteva, C. Michael Francis, Neel R. Sodha, Jean‐Francois Pittet, Brant M. Wagener, Jessica Bell, Chung‐Sik Choi, Corey E. Ventetuolo, Troy Stevens   +15 more
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Impact of Tau on Neurovascular Pathology in Alzheimer's Disease

Frontiers in Neurology, 2021
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most prevalent cause of dementia. The main cerebral histological hallmarks are represented by parenchymal insoluble deposits of amyloid beta (Aβ plaques) and neurofibrillary tangles
Elisa Canepa, Silvia Fossati
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Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity

Frontiers in Aging Neuroscience, 2021
Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules.
Luciana Medina, Florencia González-Lizárraga, Antonio Dominguez-Meijide, Antonio Dominguez-Meijide, Antonio Dominguez-Meijide, Diego Ploper, Valeria Parrales, Sabrina Sequeira, Maria-Sol Cima-Omori, Markus Zweckstetter, Markus Zweckstetter, Elaine Del Bel, Patrick P. Michel, Tiago Fleming Outeiro, Tiago Fleming Outeiro, Tiago Fleming Outeiro, Rita Raisman-Vozari, Rosana Chehín, Sergio B. Socias   +18 more
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Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

Frontiers in Neuroscience, 2017
Tauopathies are a diverse group of diseases featuring progressive dying-back neurodegeneration of specific neuronal populations in association with accumulation of abnormal forms of the microtubule-associated protein tau.
Andrew Kneynsberg, Andrew Kneynsberg, Benjamin Combs, Kyle Christensen, Kyle Christensen, Gerardo Morfini, Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan   +8 more
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Neurodegeneration in tauopathies and synucleinopathies [PDF]

Revue Neurologique, 2016
While increasing life expectancy is a major achievement, the global aging of societies raises a number of medical issues, such as the development of age-related disorders, including neurodegenerative diseases. The three main disease groups constituting the majority of neurodegenerative diseases are tauopathies, alpha-synucleinopathies and diseases due ...
Foguem, Clovis, Kamsu-Foguem, Bernard
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An unusual presentation of Huntington’s disease

Clinical Case Reports, 2021
We describe the case of a 59‐year‐old woman who exhibited psychotic symptoms, cognitive dysfunction, and restlessness. While the clinical picture and 18F‐FDG PET/CT suggested the presence of a tauopathy, especially frontotemporal dementia or progressive ...
Martin Schulze Westhoff, Alma Osmanovic, Catharina Meissner, Johannes Heck, Nima Mahmoudi, Corinna Hendrich, Georg Berding, Johanna Seifert, Stefan Bleich, Helge Frieling, Tillmann Krüger, Adrian Groh   +11 more
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