Results 71 to 80 of about 21,599 (190)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, Volume 99, Issue 6, Page 1405-1414, June 2026.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

Creutzfeldt-Jakob-like syndrome induced by lithium, levomepromazine, and phenobarbitone [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1999
Creutzfeldt-Jakob-like syndrome was first reported by Smith and Kocen1 in 1988. Its symptoms resemble Creutzfeldt-Jakob disease but it is induced by drugs, particularly lithium, and most patients recover without sequel after discontinuation of drugs. It also displays a characteristic EEG similar to Creutzfeldt-Jakob disease, but this returns to normal ...
H. KIKYO, T. FURUKAWA
openaire   +1 more source

Creutzfeldt-Jakob disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Creutzfeldt⁃Jakob disease (CJD) is a degenerative central nervous system (CNS) disease caused by infection of prion protein (PrP), with clinical features including short course, rapid development and 100% mortality.
Lin WANG, Jian-rong LIU
doaj  

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Novel prion mutation (p.Tyr225Cys) in a Korean patient with atypical Creutzfeldt–Jakob disease

Clinical Interventions in Aging, 2019
Eva Bagyinszky,1,* YoungSoon Yang,2,* Vo Van Giau,1 Young Chul Youn,3 Seong Soo A An,1 SangYun Kim41Department of Bionano Technology, Gachon University, Sungnam, Korea; 2Department of Neurology, Veteran Health Service Medical Center, Seoul, Korea ...
Bagyinszky E, Yang Y, Giau VV, Youn YC, An SSA, Kim S   +5 more
doaj  

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Coexistence of protease sensitive and resistant prion protein in 129VV homozygous sporadic Creutzfeldt–Jakob disease: a case report

Journal of Medical Case Reports, 2012
Introduction The coexistence of different molecular types of classical protease-resistant prion protein in the same individual have been described, however, the simultaneous finding of these with the recently described protease-sensitive variant or ...
Rodríguez-Martínez Ana B, de Munain Adolfo, Ferrer Isidro, Zarranz Juan J, Atarés Begoña, Villagra Nuria T, Arteagoitia Jose M, Garrido Joseba M, Juste Ramón A   +8 more
doaj   +1 more source

Bibliometric analysis of Alzheimer's and dementia research in Latin America

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Dementia is increasing rapidly in Latin America and the Caribbean (LAC), but research output remains limited. Tracking publication trends, themes, and collaborations is key to guiding regional research and policy. METHODS Bibliometric analysis was conducted on dementia‐related publications from 21 LAC countries (1990 to 2024 ...
Mauricio Vazquez‐Guajardo, Alberto J. Mimenza‐Alvarado, Carlos Alejandro Martinez‐Zamora, Angel Lee, Oscar Abraham Jose Padilla Solis, José Francisco Parodi, Nilton Santos Custodio Capuñay, Sara G. Aguilar‐Navarro   +7 more
wiley   +1 more source

Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital

Dementia and Geriatric Cognitive Disorders Extra, 2015
Background/Aims: Although delirium is generally regarded as a transient syndrome, persistence of delirium in patients with cognitive impairment - even with fatal outcome - has been reported as well.
Ingrid S. Jans, Letty Oudewortel, Paulien M. Brandt, Willem A. van Gool   +3 more
doaj   +1 more source