Results 51 to 60 of about 7,669 (173)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Creutzfeldt-Jakob disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Creutzfeldt⁃Jakob disease (CJD) is a degenerative central nervous system (CNS) disease caused by infection of prion protein (PrP), with clinical features including short course, rapid development and 100% mortality.
Lin WANG, Jian-rong LIU
doaj  

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, Volume 99, Issue 6, Page 1405-1414, June 2026.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Novel prion mutation (p.Tyr225Cys) in a Korean patient with atypical Creutzfeldt–Jakob disease

Clinical Interventions in Aging, 2019
Eva Bagyinszky,1,* YoungSoon Yang,2,* Vo Van Giau,1 Young Chul Youn,3 Seong Soo A An,1 SangYun Kim41Department of Bionano Technology, Gachon University, Sungnam, Korea; 2Department of Neurology, Veteran Health Service Medical Center, Seoul, Korea ...
Bagyinszky E, Yang Y, Giau VV, Youn YC, An SSA, Kim S   +5 more
doaj  

Coexistence of protease sensitive and resistant prion protein in 129VV homozygous sporadic Creutzfeldt–Jakob disease: a case report

Journal of Medical Case Reports, 2012
Introduction The coexistence of different molecular types of classical protease-resistant prion protein in the same individual have been described, however, the simultaneous finding of these with the recently described protease-sensitive variant or ...
Rodríguez-Martínez Ana B, de Munain Adolfo, Ferrer Isidro, Zarranz Juan J, Atarés Begoña, Villagra Nuria T, Arteagoitia Jose M, Garrido Joseba M, Juste Ramón A   +8 more
doaj   +1 more source

National Creutzfeldt–Jakob disease research biobank, a novel approach to the establishment of the scientific platform: collaboration between patient advocacy group, scientists, regulators and physicians

Orphanet Journal of Rare Diseases
Creutzfeldt–Jakob disease (CJD) is a severe neurodegenerative disorder characterized by the abnormal accumulation of prion proteins. In Israel, a unique epidemiological pattern of CJD has been identified, specifically a genetic form (gCJD) associated ...
Alice Anane, Doron Pasternak, Shimon A. Reisner, Victor Novack   +3 more
doaj   +1 more source

A Corticobasal Syndrome Variant of Familial Creutzfeldt-Jakob Disease with Stroke-Like Onset

Case Reports in Neurological Medicine, 2016
Creutzfeldt-Jakob disease (CJD) is an untreatable rare human prion disease characterized by rapidly progressive dementia along with various neurological features, including myoclonus and sometimes other movement disorders.
Ján Necpál, Martin Stelzer, Silvia Koščová, Michal Patarák   +3 more
doaj   +1 more source

Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital

Dementia and Geriatric Cognitive Disorders Extra, 2015
Background/Aims: Although delirium is generally regarded as a transient syndrome, persistence of delirium in patients with cognitive impairment - even with fatal outcome - has been reported as well.
Ingrid S. Jans, Letty Oudewortel, Paulien M. Brandt, Willem A. van Gool   +3 more
doaj   +1 more source

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

Acta Neuropathologica Communications, 2019
For the transmissible, neurogenerative family of prion diseases, few human models of infection exist and none represent structured neuronal tissue. Human cerebral organoids are self-organizing, three-dimensional brain tissues that can be grown from ...
Bradley R. Groveman, Simote T. Foliaki, Christina D. Orru, Gianluigi Zanusso, James A. Carroll, Brent Race, Cathryn L. Haigh   +6 more
doaj   +1 more source