Results 51 to 60 of about 13,613 (255)
Creutzfeldt-Jakob disease and sleep disorders
Chinese Journal of Contemporary Neurology and Neurosurgery, 2018 Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by prion protein infection. Compared with other neurodegenerative diseases, neuronal cell apoptosis in CJD occurs more rapidly.
Jian-nan ZHU +5 more
doaj +1 more source
Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob Disease
Diagnostics, 2020 Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare fatal degenerative disease of the central nervous system. The clinical course is characterized by rapid progression of neurological and neuromuscular symptoms.
Stefan M. Golaszewski +11 more
doaj +1 more source
Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon [PDF]
, 1991 Current models of the virus-like agents of scrapie and bovine spongiform encephalopathy (BSE) have to take into account that structural changes in a host-encoded protein (PrP protein) exhibit an effect on the time course of these diseases and the ...
Dawson, M +4 more
core +2 more sources
Imaging and CSF analyses effectively distinguish CJD from its mimics [PDF]
, 2017 OBJECTIVE: To review clinical and investigation findings in patients referred to a specialist prion clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to have an alternative final diagnosis. METHODS: Review the
Collinge, J +4 more
core +1 more source
Prion disease: experimental models and reality [PDF]
, 2017 The understanding of the pathogenesis and mechanisms of diseases requires a multidisciplinary approach, involving clinical observation, correlation to pathological processes, and modelling of disease mechanisms.
Brandner, S, Jaunmuktane, Z
core +1 more source
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram +10 more
wiley +1 more source
Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism
Annals of Neurology, EarlyView.Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono +5 more
wiley +1 more source
MicroRNAs in Prion Diseases—From Molecular Mechanisms to Insights in Translational Medicine
Cells, 2021 MicroRNAs (miRNAs) are small non-coding RNA molecules able to post-transcriptionally regulate gene expression via base-pairing with partially complementary sequences of target transcripts.
Danyel Fernandes Contiliani +3 more
doaj +1 more source
Gerstmann-Straussler-Scheinker disease in an Alsatian family: clinical and genetic studies [PDF]
, 1992 The clinical progression of Gerstmann-Straussler-Scheinker disease in a family of Alsatian origin is reported. The age of onset and the duration of evolution were variable.
Chevalier, Y +10 more
core +1 more source