Results 141 to 150 of about 48,713 (266)

Steroid Withdrawal Syndrome and Adrenal Insufficiency Following Unsupervised Steroid Use: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT We report a 65‐year‐old female with prolonged unsupervised corticosteroid use who developed exogenous Cushing syndrome, recurrent infection, and adrenal crisis following abrupt withdrawal.
Samit Kumar Gautam, Shardul Bhattarai, Aastha Dhakal, Kushal Acharya, Binay Khadka, Ganesh Lama, Milan Shakya, Alok Dhungel   +7 more
wiley   +1 more source

Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc‐fusion protein SL‐172154 (SIRPα‐Fc‐CD40L) in patients with higher‐risk myelodysplastic syndrome or acute myeloid leukemia

Cancer, Volume 132, Issue 19, 1 October 2026.
Abstract Background This clinical trial sought to determine whether SL‐172154 could be combined safely and improve the efficacy of azacitidine (AZA) in patients with higher‐risk myelodysplastic syndrome (HR‐MDS) or acute myeloid leukemia (AML). Methods Dose escalation: doses of 1, 3, and 6 mg/kg SL‐172154 was evaluated as monotherapy or in combination ...
Naval G. Daver, Amer M. Zeidan, Anthony S. Stein, Joshua F. Zeidner, Keri Maher, Emily Curran, Dale Bixby, Wanxing Chai‐Ho, Maximilian Stahl, Karen W. L. Yee, Don Stevens, Sawa Ito, Jana Reynolds, Patrick Medd, Emma Searle, Andrew Sochacki, Mary Lynn Savoie, Steven Green, Kazunobu Kato, Robert Hernandez, Simon Metenou, Bo Ma, Lini Pandite, Taylor H. Schreiber, David A. Sallman   +24 more
wiley   +1 more source

Trigeminal Nerve Stimulation for Disorders of Consciousness: A Narrative Review of Potential Mechanisms, Clinical Evidence, and Future Perspectives

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Preclinical studies indicate that Trigeminal Nerve Stimulation (TNS) treats Disorders of Consciousness (DoC) by activating neural pathways that promote the release of orexin, dopamine, and norepinephrine. Additionally, TNS modulates cerebral hemodynamics and immunoregulation to enhance consciousness in experimental animals.
Haodong Niu, Yilin Zhang, Nan Wang, Xiaoke Chai, Yiyi Zhai, Zhiyao Zheng, Yangxi Xu, Yitong Jia, Kefei Wan, Sipeng Zhu, Tianqing Cao, Qiheng He, Minghao Liu, Zhuoyang Li, Yichen Wang, Haitao Huang, Juanning Si, Yi Yang, Jizong Zhao   +18 more
wiley   +1 more source

Integrative Transcriptomics and Machine Learning Identify Temporal Stress Signatures and Astrocytic Neurocan Associated With Hypothalamic Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Our research journey revealed a clear split: mRNAs track stress stages, while miRNAs sense stress states. We built a validated predictive model from just 6 markers. The star was Ncan—an astrocytic proteoglycan—which restored neuronal nets and eased depression; virtual knockout confirmed its central role in stress networks.
Weihao Zhu, Chenyu Li, Mengting He, Rui Shi, Xia Liu, Weibo Shi, Bin Cong   +6 more
wiley   +1 more source

EVALUATION OF CORTICOTROPIN RELEASING HORMONE (CRH) IN PREECLAMPSIA

Pakistan Armed Forces Medical Journal, 2010
Background: CRH level is increased during normal pregnancy as it is released from the placenta. This implies a definite role of CRH in pregnancy or labor.
Dr Asmat Kamal Ansari, Salma Farrukh Memon, Shahzeen Fatima   +2 more
doaj  

Neuropathic Pain Comorbid Cognitive Impairment and Vitamin D: A Narrative Review From Mechanisms to Clinical Management

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Vitamin D is an essential fat‐soluble nutrient primarily obtained through cutaneous synthesis triggered by ultraviolet exposure and dietary intake. After systemic metabolism and activation, it binds to vitamin D receptors widely distributed in the central and peripheral nervous systems, exerting pleiotropic neuroprotective and regulatory biological ...
Nan Zhao, Yang Yang, Wanqiu Yu, Yuhang Zhu, Zhaoqiong Zhu   +4 more
wiley   +1 more source

Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists

Corticotropin-releasing hormone (CRH) plays a major role in coordinating the behavioral, endocrine, autonomic and immune responses to stress. CRH and CRH-related peptides and their receptors are present in the central nervous system and in a wide variety

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Coreopsis tinctoria Nutt. Polyphenols Ameliorate CUMS‐Induced Depressive Behaviors and Hippocampal Neuronal Damage in Mice

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
The capitula of Coreopsis tinctoria Nutt. polyphenol extract (CCTE) attenuate CUMS‐induced depressive‐like behaviors and hippocampal neuronal damage in mice. Three flavonoid aglycones—okanin, isookanin, and taxifolin—cross the blood–brain barrier and synergistically inhibit MAO‐A, restoring serotonergic tone; concurrently, CCTE normalizes HPA‐axis ...
Haixia Han, Yujing Feng, Zhen Wang, Rui Ma, Jingjing Sun, Xiuli Yang, Yue Cui, Juan Wang, Mingxi Jia   +8 more
wiley   +1 more source

CRH [PDF]

, 2019
openaire   +1 more source

Generation of Anti-rat CRH-Receptor (CRH-R) Antibody and Distribution of CRH-R in the Rat

Folia Endocrinologica Japonica, 1996
OKURA, Toshihiro, ZHANG, Chen-Yu, FUJINAKA, Yuichi, YOKOGOSHI, Yutaka, HISANO, Setsuji, KITAGAWA, Kouki, SAITO, Shiro   +6 more
openaire   +2 more sources