Results 141 to 150 of about 4,257,137 (288)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Crisis… ¿Qué crisis?

Revista del Hospital Italiano de Buenos Aires
Proyecto DER2016-77924-P, “Los derechos fundamentales ante las crisis económicas y de seguridad en un marco constitucional fragmentado” (MINECO 2016)
openaire   +3 more sources

Telomere Crisis Shapes Cancer Evolution. [PDF]

Cold Spring Harb Perspect Biol
Nassour J, Karlseder J.
europepmc   +1 more source

Towards a Lasting Peace in Nepal: The Constitutional Issues [PDF]

, 2005
International Crisis Group
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Climate crisis and food access in Brazilian favelas: a territorial justice agenda. [PDF]

Lancet Reg Health Am
Vieira LL, Rocha LL, Oliveira EP, Mendes LL.   +3 more
europepmc   +1 more source

Nepal: Back to the Gun [PDF]

, 2003
International Crisis Group
core  

Financial Crisis and Crisis Management in Sweden. Lessons for Today [PDF]

This paper gives an account of the Swedish financial crisis covering the period 1985–2000, dealing with financial deregulation and the boom in the late 1980s, the bust and the financial crisis in the early 1990s, the recovery from the crisis and the bank
Jonung, Lars
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Nepal's Future: In Whose Hands? [PDF]

, 2009
International Crisis Group
core