Results 141 to 150 of about 5,089,545 (386)

The monetary mechanics of the crisis [PDF]

In response to the financial and economic crisis, central banks, unlike in the 1930s, have created enormous amounts of money. There are fears that this will lead to inflation, but it is base money (the central bank's liabilities) that has expanded; total
Jürgen von Hagen
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Adrenal Crisis [PDF]

, 2019
Glucocorticoid replacement therapy, available since the 1950s, has prolonged the survival of patients with adrenal insufficiency. However, adrenal crises, which are life-threatening medical emergencies, still develop in many affected patients.
Falhammar, Henrik, Rushworth, R Louise, Torpy, David J   +2 more
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Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Cultural Factors in the Chinese Crisis [PDF]

, 1900
Paui S. Reinsch
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Nascent island tourism policy development in Greenland: A network perspective

Island Studies Journal, 2019
Following its achievement of Self-Rule status in 2009 Greenland embarked on a series of measures to diversify its economy with an eye towards eventually gaining full independence from Denmark. Tourism was underlined as a key sector for reaching this goal
Evangelia Petridou, Pär M. Olausson, Dimitri Ioannides   +2 more
doaj   +1 more source

THE CRISIS IN SCIENCE AND MATHEMATICS TEACHING [PDF]

, 1947
Raleigh Schooling
openalex   +1 more source

Crisis? What crisis? Australia after(?) the economic crisis [PDF]

The global economic crisis is not over for Australia. Instead, its effects have been delayed rather than avoided. China’s economic stimulus delayed the impact of the crisis, but as Chinese economy rebalances and its growth slows, Australian policy-makers
Tom Conley
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Confronting the Crisis [PDF]

, 2005
The eight major focus areas of this document include: schools and education; shelter and housing; jobs and life skills; after-school time; mental health, substance abuse, and HIV;violence and victimization; Latino/a LGBTQ youth; and transgender ...

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