Results 201 to 210 of about 4,257,137 (288)

Emergency use of eculizumab in impending and manifest myasthenic crisis: a retrospective case series. [PDF]

Ther Adv Neurol Disord
Huang Y, Xiong Y, Zhan H, Wu F, Jiang Y, Zhang Y, Chen J, Zeng S, Zhang T, Xiong X, Chen Z, Yang F, Li G, Xu Q.   +13 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Temperature extremes contribute to suicide-related help-seeking through multiple pathways: Evidence from crisis hotline data (2019-2023). [PDF]

PLOS Ment Health
Ryan SC, Sugg MM, Schwandt V, Crespo S, Lindzey S, Runkle JD.   +5 more
europepmc   +1 more source

Nepals Election and Beyond [PDF]

, 2008
International Crisis Group
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Patterns of herbal medicine utilization for hypertension during the Sudanese crisis of 2025. [PDF]

Sci Rep
Sidahmed TSM, Hassan AAE, El-Haj AMOK, Almosilhy NA, Mahmoud SAS, Mohammed MOO, Ali AEO, Hassan FAO, Ibrahim WSM, Abedalla MMH, Ahmed MAO, Abdallah WSA, Abdalla OAA, Hamza KMA, Mohammed KAA.   +14 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Psychiatric advance directives: challenges emerging from implementation and possible steps forward. [PDF]

World Psychiatry
Swartz MS, Swanson JW.
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Climate, conflict, and food security: a systematic review of household-level evidence (2020-2025). [PDF]

J Health Popul Nutr
Awoke MD, Brück T.
europepmc   +1 more source