Results 201 to 210 of about 1,767,410 (336)

Opioid Crisis: No Easy Fix to Its Social and Economic Determinants.

American Journal of Public Health, 2018
N. Dasgupta, L. Beletsky, D. Ciccarone
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Adrenal Crisis Masquerading as Sepsis in a Patient With Autoimmune Multimorbidity: A Diagnostic Challenge on the Acute Medical Ward. [PDF]

Cureus
Reyad B, Aldawoody H.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

1-Year Clinical Outcome Post-Myasthenic Crisis: A Multicenter Prospective Study in China. [PDF]

Eur J Neurol
Huan X, Chen R, Jin L, Wang Y, Xu Y, Yang L, Xi C, Zheng J, Luo L, Yang S, Shi J, Liu Y, Ruan Z, Wu W, Li W, Yue Y, Li Y, Jia W, Zhong H, Yan C, Song J, Xi J, Tan S, Jiang Q, Zou Z, Zhao C, Luo S, Chinese Myasthenia Gravis Collaborating Group (CMGCG).   +27 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Prolonged alpha-blockade and doxazosin are associated with hypertensive crisis in pheochromocytoma surgery. [PDF]

Front Endocrinol (Lausanne)
Zawadzka K, Pisarska-Adamczyk M, Hubalewska-Dydejczyk A, Pędziwiatr M.   +3 more
europepmc   +1 more source

The European Trust Crisis and the Rise of Populism

, 2017
Y. Algan, S. Guriev, E. Papaioannou, Evgenia Passari   +3 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Predicting imminent suicide risk in a crisis hotline chat using machine learning. [PDF]

Sci Rep
Levi-Belz Y, Grimland M, Segal-Elbak Y, Munz N, Yeshayahu H, Benatov J, Segal A, Ben Dayan L, Shenfeld I, Gal K.   +9 more
europepmc   +1 more source