Results 211 to 220 of about 4,533,202 (342)

Nepal's New Political Landscape [PDF]

open access: yes, 2008
International Crisis Group
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Nepal's Fragile Peace Process [PDF]

open access: yes, 2007
International Crisis Group
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Care for survivors when an emergency ends. [PDF]

open access: yesBull World Health Organ
Kamil A, Farooq AR.
europepmc   +1 more source

Nepal's Royal Coup: Making a Bad Situation Worse [PDF]

open access: yes, 2005
International Crisis Group
core  

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