Results 61 to 70 of about 5,358,439 (388)

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

The Changing Opioid Crisis: development, challenges and opportunities

open access: yesMolecular Psychiatry, 2020
The current opioid epidemic is one of the most severe public health crisis in US history. Responding to it has been difficult due to its rapidly changing nature and the severity of its associated outcomes. This review examines the origin and evolution of
N. Volkow, C. Blanco
semanticscholar   +1 more source

Sanitary Crisis, Civilizational Crisis [PDF]

open access: yesSpace and Culture, 2020
Sanitary Crisis, Civilizational Crisis is the translation of Michel Maffesoli’s Crise sanitaire, crise civilisationnelle. This paper can be taken as his pronouncement on the civilizational crisis that the COVID-19 pandemic acutely reveals. Maffesoli’s text urges one to see beyond secondary causes or dramatic representations of the pandemic as a ...
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

The digitalization and public crisis responses of small and medium enterprises: Implications from a COVID-19 survey

open access: yesFrontiers of Business Research in China, 2020
The COVID-19 outbreak is a global crisis that has placed small and medium enterprises (SMEs) under huge pressure to survive, requiring them to respond effectively to the crisis.
Hai Guo, Zhuen Yang, Ran Huang, Anqi Guo
semanticscholar   +1 more source

The Theory Crisis in Psychology: How to Move Forward

open access: yesPerspectives on Psychological Science, 2021
Meehl argued in 1978 that theories in psychology come and go, with little cumulative progress. We believe that this assessment still holds, as also evidenced by increasingly common claims that psychology is facing a “theory crisis” and that psychologists
M. Eronen, L. Bringmann
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

THE PROBLEM OF QUALITY OF THE FINANCIAL ANALYSIS IN INSOLVENCY (BANCRUPTCY) PROCEDURES

open access: yesСтратегические решения и риск-менеджмент, 2015
It examines the role of financial analysis in the contemporary system of insolvency management, based on many years of practical experience, explores the сauses of poor quality of analytical procedures and the typical shortcomings of financial ...
N. G. Akulova, D. I. Ryakhovsky
doaj   +1 more source

The Interpersonal Style and Complementarity Between Crisis Negotiators and Forensic Inpatients [PDF]

open access: yes, 2011
Previous negotiation research has explored the interaction and communication between crisis negotiators and perpetrators. A crisis negotiator attempts to resolve a critical incident through negotiation with an individual, or group of persons in crisis ...
A Dolink   +24 more
core   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

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