Results 151 to 160 of about 2,102,245 (304)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Cancer without borders: Policy frameworks for oncology care in humanitarian and conflict settings. [PDF]

Oncotarget
Parmar P, Rathod G.
europepmc   +1 more source

SUSTAINABLE DEVELOPMENT IN THE GLOBAL ECONOMY [PDF]

The actual paper comes with an approach regarding the sustainable development in today’s world and the global economy. The way of proceeding is the following: the main causes of the current economic crisis are analyzed and it is demonstrated that ...
Drd. Anagnoste Sorin, Prep. Univ. Drd. Agoston Simona   +1 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Sustaining policy promise: rhetorics of disease elimination and sustainable development. [PDF]

Med Humanit
Rhodes T.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

WHO's 2026 emergency appeal and global health security. [PDF]

Global Health
Abdi YH, Bashir SG, Osman WA, Abdulle AA.   +3 more
europepmc   +1 more source

Fiscal Policy: Lessons from the Global Crisis [PDF]

The global crisis interacted heavily with fiscal policy in the run-up to the crisis, during the crisis and now in the recovery phase. Contrary to the general consensus, the paper argues that in the run-up to the crisis, fiscal policy in the advanced ...
Neven Mates
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

EconoGNN: A graph neural network framework for temporal economic resilience insights. [PDF]

PLoS One
Araujo M, Rodrigues F, Sousa E.
europepmc   +1 more source