Results 171 to 180 of about 6,226,749 (260)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Depression - The global crisis

Indian Journal of Psychological Medicine, 2012
M S Reddy
doaj   +1 more source

Social Support and Mental Health Across a Public Health Crisis Lifecycle: A Three-Wave Repeated Cross-Sectional Study of Mediating Coping Mechanisms. [PDF]

Psychol Res Behav Manag
Xu S, Wang W, Cao K, Shi C.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Reflexiones frente a la crisis global

Cultura Económica, 2019
Luk Bouckaert, Charles Wilber, Helen Alford OP, Ricardo Crespo, Miguel Alfonso Martínez Echevarría y Ortega, Michael Naughton, José Luis Widow Lira, Simona Beretta, Samuel Gregg, Carlos Hoevel   +9 more
doaj  

The Strait of Hormuz and global antibiotic security. [PDF]

Br J Gen Pract
Nejadghaderi SA, Moghaddam SS, Razai MS, Sharifi H, Stolpe M.   +4 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Crisis readiness for rare disease populations: learnings and recommendations by the European Reference Networks. [PDF]

Lancet Reg Health Eur
Dollfus H, Arzimanoglou A, Evangelista T, Graessner H, Mosca M, Sangiorgi L, Blay JY, Bodemer C, Fenaux P, Hernández F, Jondeau G, Ligtenberg MJL, Lohse AW, Mathijssen IMJ, Mulders P, Pereira AM, Schaefer F, Swart JF, Verloes A, Wagner TOF, Wijnen RMH, Wilde AAM, Pereira MDMM, Ladenstein R, Scarpa M.   +24 more
europepmc   +1 more source