Results 131 to 140 of about 3,275,688 (215)
BMC PsychologyBackground While peer rejection and depressive symptoms are robustly linked in adolescents, their directional relationships and underlying mechanisms remain unclear, especially in Chinese cultural contexts and mid- to late adolescence.
Yuelin Chen, Zihan Xie, Ying Yang
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Intervention index and exchange rate regimes: the cases of selected East-Asian economies [PDF]
Given the absence of publicly available information on foreign exchange intervention, we propose an index of central bank intervention in the exchange market to classify exchange rate regimes adopted by four East Asian economies. We revisit an old debate
Siregar, Reza, Pontines, Victor
core
Attitudinal Change of officers that are Crisis Intervention Trained. A workplace Project
Mental health incidences increase every year, impacting the resources of emergency services, including police and paramedics, who respond to calls for service.
Giles, Gregory
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Irish contraception and crisis pregnancy [ICCP] study: A survey of the general population
, 2004 Crisis pregnancy is a complex challenge for individuals and societies alike. Its prevention and management needs to be informed by up-to-date and locally applicable information on knowledge, attitudes and behaviours concerning sexual practices and ...
McGee, Hannah +3 more
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Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
International Reserves and the Global Financial Crisis [PDF]
This study examines whether pre-crisis international reserve accumulations, as well as exchange rate and reserve policy decisions made during the global financial crisis, can help to explain cross-country differences in post-crisis economic performance ...
Kathryn M.E. Dominguez +2 more
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