Results 141 to 150 of about 4,883,379 (297)

Impact of crisis intervention on mental health in the context of specific civilian emergencies. [PDF]

PLoS One
Hu X, Liu J, Hao B, Lv Y.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Suicide prevention starts before the crisis: intervention guidelines for university students. [PDF]

Psicol Reflex Crit
Cecchin HFG, Murta SG.
europepmc   +1 more source

Psychological Crisis Intervention for COVID-19 Lockdown Stress in Patients With Type 1 Diabetes Mellitus: Survey Study and Qualitative Analysis. [PDF]

JMIR Ment Health, 2021
Cyranka K, Dudek D, Małecki MT, Matejko B, Klupa T.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Suicidal behaviour in adolescents with affective disorders: A study in a crisis intervention unit (CIU). [PDF]

PLoS One
Valdevila Figueira JA, Valdevila Figueira JA, Espinoza de Los Monteros Andrade MA, Valdevila Santiesteban R, Ramírez A, Carvajal Parra ID, Martin Delgado JD, Martínez-Suárez PC, Benenaula Vargas LP, Andrade Hidalgo ME, Rodas JA.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Crisis Intervention Team Mental Health Training for Law Enforcement Officers: Protocol for a Multi-Site, Randomized, Controlled Trial. [PDF]

Psychiatr Res Clin Pract
Compton MT, Jackson E, Fu E, Andrews HF, Bruno R, Comartin E, Galfalvy H, Kamin D, Pope LG, Vega E, Watson AC.   +10 more
europepmc   +1 more source

Association of Stress-Related Factors With Anxiety Among Chinese Pregnant Participants in an Online Crisis Intervention During COVID-19 Epidemic. [PDF]

Front Psychol, 2021
Shangguan F, Wang R, Quan X, Zhou C, Zhang C, Qian W, Zhou Y, Liu Z, Zhang XY.   +8 more
europepmc   +1 more source