Results 151 to 160 of about 268,247 (301)

The impact of socioeconomic crisis on cancer patient outcomes in Lebanon, 2018-2020. [PDF]

open access: yesJ Comp Eff Res
Ladner J   +5 more
europepmc   +1 more source

Vulnerability to Hunger: Improving Food Crisis Responses in Fragile States [PDF]

open access: yes
The paper examines the imperative for improved classification and analysis of food crises in different fragile contexts. Recognizing the persistence and protracted nature of food crises, the paper questions how prevention and response mechanisms could be
Andrews, Colin, Flores, Margarita
core  

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

open access: yesAdvanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu   +20 more
wiley   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

open access: yesAdvanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao   +6 more
wiley   +1 more source

Dynamic and Structure of the Italian stock market based on returns and volume trading [PDF]

open access: yes
In this paper we introduce a new method to describe dynamical patterns of multidimensional time. The method combines the tools of Symbolic Time Series Analysis with the nearest neighbor single linkage clustering algorithm.
Juan Gabriel Brida, W. Adrian Risso
core  

Multidimensional Security and Latin American Integration in Times of Crisis

open access: yesIBEROAMERICA, 2020
Lazar Jeifets, Kseniya Konovalova
openaire   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

open access: yesAdvanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu   +11 more
wiley   +1 more source

Regional differentiation in the Russian federation: A cluster-based typification [PDF]

open access: yes
The paper gives a socio-economic analysis of the 89 regions of the Russian Federation. This analysis is implemented in four steps: 1) elaboration of a set of indicators defining the socio-economic situation in all 89 regions of the Russian Federation ...
Boris Frolov   +3 more
core  

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