Results 141 to 150 of about 19,765 (302)
, 2009 Unlike the previous economic crises of the past two decades which have occurred in Asia, Russia, Mexico and Argentina, the present crisis of capital occurred at the centre of the globalized economy: the United States of America.
Cottle, Drew (R7509) +2 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The “Crisis of Humanities” and Contemporary Challenges
Humanities are the foundation of all sciences. Although the term has been established since the Middle Ages, its meaning was changing over time. In the era of postmodernism, humanitarian sciences include those academic disciplines that are focused on the
ხუციშვილი, ქეთევან / Khutsishvili, Ketevan
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Media and power in times of hegemonic crisis : exploring contentious climate politics on Twitter
During moments of hegemonic crisis, it is crucial to understand the dynamics of media power. This article identifies key structural forces and disruptive tendencies that are factors in a current crisis of the neoliberal hegemonic order. This intellectual
Tegelberg, Matthew +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Disintegrating ipseity: a gerontological exegesis of Alzheimer's disease and relational identity in Alice Munro's fiction. [PDF]
Philos Ethics Humanit MedUllah F, Du S, Jin W, Nagar YA.
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Possibilities for the peer review of interdisciplinary research: a small-scale qualitative study. [PDF]
Res Integr Peer RevVesma G.
europepmc +1 more source