Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
(Re)positioning humanities in the Malaysian higher education landscape
, 2018 This paper discusses the humanities and humanities education, which is inevitably embedded in the context of a re-assessment of the role and functions of universities in the current and future Industry 4.0 environment.
Anis Amalina
core
Promoting psychological crisis coping through physical activity: The mediating roles of rumination and emotion regulation among college students. [PDF]
PLoS OneYang Y, Lu B, Wang S.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Editorial: Enhancing public health workforce competencies: AI integration and post-pandemic educational reforms. [PDF]
Front Public HealthSu Z +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ian McWhinney and the doctor-patient relationship: Part 2 of the 10-part series, "Foundations for tomorrow". [PDF]
Can Fam PhysicianHin ANC.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Silent "Teacher": A Conceptual Framework and Teaching Model for Cultivating Medical Humanities in Morphological Experiments. [PDF]
Adv Med Educ PractChai G, Zhai X.
europepmc +1 more source
CATTLE TB CRISIS? HUMAN IMPLICATIONS [PDF]
Letters in Applied Microbiology, 1998 openaire +3 more sources