Results 81 to 90 of about 19,765 (302)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
, 1989 The intent of this study is to place the widely-debated humanities crisis of the 1980s in cultural context, to unravel the discourse of crisis in order to examine what it signifies.
Warehime, Nancy
core +1 more source
Vpliv gospodarskih razmer na zaposlovanje diplomantov
Economic and Business Review, 2019 During the recent economic crisis, new generations of college graduates have entered the labor market each year facing lower labor demand, which has severely affected their transition into the labor market.
Daša Farčnik, Polona Domadenik
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Journal for Perspectives of Economic Political and Social Integration, 2017 In this article, I discuss the nature, causes and effects of the crisis of civilization which we can observe for over forty years. This crisis affects social order, with its economic, institutional and demographic dimensions, as well as the culture and ...
Wielecki Krzysztof
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Crisis: the exception that became rule
Revista Maracanan, 2018 This dossier was conceived in the context of unprecedented crisis experienced by the University of the State of Rio de Janeiro (UERJ). It has been becoming alarming since at least 2015.
Beatriz Vieira +2 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Ku laboratorium humanistycznemu
Teksty Drugie, 2017 This article is an attempt to think about the ‘laboratization’ of the humanities on the metalevel. Building on Bruno Latour’s essay ‘Give Me a Laboratory and I Will Move the World,’ the authors explore if and how the laboratory can renew the humanities ...
Aleksandra Kil +2 more
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