Results 81 to 90 of about 12,146 (263)

The role of school history in helping young people to navigate their future at a time of climate crisis

History Education Research Journal
The need to prepare school students to respond to the climate and environmental crises is rapidly rising up educational agendas nationally and internationally, but the role of the humanities, and particularly history, is often marginalised.
doaj   +2 more sources

Towards Innovative Humanities: The Text as a Laboratory. Traditions, Hypotheses, Ideas

Teksty Drugie, 2015
The article provides a comment on the current debate over arts and science and on academic politics. The perspective of the so-called “technouniversity” leads to the progressive marginalisation of the humanities whose critical evaluation is based on the ...
Ryszard Nycz
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Debatir el Antropoceno desde el estructuralismo y el materialismo ecofeminista

Relaciones Internacionales, 2021
Debatir el Antropoceno desde el estructuralismo y el materialismo ecofeminista   Barca, S. (2020). Forces of Reproduction. Notes for a Counter-Hegemonic Anthropocene. Elements in Environmental Humanities. Cambridge University Press. Moore, J.
Rebeca Giménez González
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The Crisis of Human Rights Discourse

PRAWO i WIĘŹ
Although the “crisis” of human rights discourse has many aspects, it is hard not to get the impression that the most important of them is the incorrect understanding of the philosophical foundations of these rights. The paper presents various hypotheses regarding the nature of this error. The first hypothesis suggests that this crisis simply stems from
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source