Results 41 to 50 of about 4,504,034 (251)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Parallelization Performances of PMSS Flow and Dispersion Modeling System over a Huge Urban Area
Atmosphere, 2019 The use of modeling as a support tool for crisis management and decision planning requires fast simulations in complex built-up areas. The Parallel Micro SWIFT SPRAY (PMSS) modeling system offers a tradeoff between accuracy and fast calculations, while ...
Oliver Oldrini +3 more
doaj +1 more source
Using EMDR therapy with patients in an acute mental health crisis
BMC Psychiatry, 2020 Background Death by suicide continues to be a global public health concern with little research demonstrating the effectiveness of treatment options.
Simon Proudlock, Jasmine Peris
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Bilateral adrenal pheochromocytomas in a 14 year-old boy
Journal of Pediatric Surgery Case Reports, 2019 Introduction: Pheochromocytomas are catecholamine-secreting tumors arise from chromaffin cells of the adrenal medulla. Classical symptoms include palpitations, headaches, sweating and paroxysmal hypertension as a result of elevated catecolamine ...
Vanessa Lini Gunawan +7 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
International Journal of Mental Health Systems, 2011 Background Crisis resolution and home treatment (CRHT) is one of the more recent modes of delivering acute mental health care in the community. The objective of the study was to describe the standardizations and variations in the CRHT teams in Norway in ...
Eklund Marthe +3 more
doaj +1 more source
Health and Social Care Delivery Research, 2023 Background Mental health crises cause significant disruption to individuals and families and can be life-threatening. The large number of community crisis services operating in an inter-agency landscape complicates access to help.
Clibbens Nicola +8 more
doaj +1 more source
Crisis resolution: A service response to mental distress
, 2010 Crisis Resolution Teams (CRTs) along with other specialist mental health teams (Early Intervention and Assertive Outreach) have emerged as a definite service direction in secondary mental health services and are firmlyembedded in mental health policy ...
Morton, JW
core +1 more source