Results 111 to 120 of about 58,732 (256)

Paediatric mental health liaison services in England: findings from a national survey

BMC Health Services Research
Background Paediatric Mental Health Liaison (PMHL) in England is poorly understood with limited data on services previously collected. Aim To describe the characteristics of PMHL services in England and create a service model typology.
Miriam Avery, Sue Kirk, Steven Pryjmachuk, William Lee, Kate Welsh   +4 more
doaj   +1 more source

Trying to create order in chaos—healthcare workers’ perspective of COVID-19 intensive care (a qualitative study)

BMJ Open Quality
Introduction The COVID-19 pandemic flooded intensive care units with patients needing supportive care. In Scandinavia, the greater Stockholm area was among the most affected.
Walter Osika, Lisbet Meurling, Cecilia Escher, Johan Creutzfeldt, Oili Dahl, Mini Ruiz, Mats Ericson   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Crisis Standards of Care: A Systems Framework for Catastrophic Disaster Response

, 2012
In 2011 alone, a tornado devastated Joplin, Missouri, and earthquakes rocked New Zealand and Japan, underscoring how quickly and completely health systems can be overwhelmed.
Viswanathan, Kristin, Gostin, Lawrence O, JD, Hanfling, Dan, MD, Altevogt, Bruce M, PhD   +3 more
core  

The impact of Covid-19 on inter-organizational coordination in Swedish eldercare: a mixed methods study

BMC Health Services Research
Background In Sweden, healthcare provision for the frail elderly entails coordination between municipalities and regions. Despite formal agreements, deficiencies persist in achieving practical coordination, leading to adverse effects on patients and ...
Sébastien Lindhagen, Anton Modigh, Ulrika Winblad   +2 more
doaj   +1 more source

Standards of Care in Crisis [PDF]

Circulation: Cardiovascular Interventions, 2020
Nino Mihatov, Ajay J. Kirtane
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Nurses’ lived experiences of self-control in emergency settings: a qualitative study

BMC Emergency Medicine
Background Given nurses’ vital role in emergencies, it is essential to understand their perceptions and strategies for self-control. This study examines nurses’ experiences and insights regarding self-control during high-pressure scenarios.
Mehraban Shahmari, Seemin Dashti, Mahsa Jafari, Fatemeh Ebrahimi Belil   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source