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CRISPR-Cas9 in cancer therapeutics
2021Cancer is a disease mainly caused by an accumulation of mutations in cells. Consequently, correcting those genetic aberrations could be a potential treatment strategy. The traditional route for cancer drug development is tedious, laborious, and time-consuming.
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CRISPR Cas9 − Licensing the unlicensable
Journal of Biotechnology, 2018A new gene engineering technology has recently made it through the media, not only because of its technical advantages, but also because it is in the focus of an epic patent battle between two academic institutions. The technology bears the cryptic name "CRISPR Cas9", and allows the manipulation of genes (so called "gene editing") with so far unseen ...
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Controlling CRISPR-Cas9 Gene Editing
New England Journal of Medicine, 2019Cracking Down on CRISPR-Cas9 Off-target DNA editing by the CRISPR-Cas9 ribonucleoprotein nuclease in the experimental treatment of genetic disease is a safety concern.
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Catching CRISPR-Cas9 in Action
Journal of Chemical Theory and ComputationCRISPR-Cas9 has revolutionized genome editing, yet its structural dynamics and functional properties remain incompletely understood, partly due to limited atomic-level characterization of its active conformation with a full R-loop. Capitalizing on recent advances in Cas9 structural determination, we constructed a catalytic-state Cas9 model bound to a ...
Yingjie Chen +5 more
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