Results 101 to 110 of about 717,978 (310)
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
A use/disuse paradigm for CRISPR-Cas systems [PDF]
Biology & Philosophy, 2019 In his insightful review, Eugene V. Koonin discusses various aspects of CRISPR-Cas systems with a strong focus on their qualities as "adaptive (acquired) immune systems"(Koonin 2018, 3). The CRISPR-Cas system is most famous for its application as a gene-editing tool. Koonin provides a deeper insight into its biological function in bacteria, which is to
openaire +4 more sources
A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer
Advanced Science, EarlyView.The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang +6 more
wiley +1 more source
AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
Advanced Science, EarlyView.Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu +8 more
wiley +1 more source
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Advanced Science, EarlyView.This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao +15 more
wiley +1 more source
Linearly repetitive Delone systems have a finite number of non periodic Delone system factors [PDF]
arXiv, 2008 We prove linearly repetitive Delone systems have finitely many Delone system factors up to conjugacy. This result is also applicable to linearly repetitive tiling systems.
arxiv
An Networked HIL Simulation System for Modeling Large-scale Power Systems [PDF]
arXiv, 2020 This paper presents a network hardware-in-the-loop (HIL) simulation system for modeling large-scale power systems. Researchers have developed many HIL test systems for power systems in recent years. Those test systems can model both microsecond-level dynamic responses of power electronic systems and millisecond-level transients of transmission and ...
arxiv
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Integral equivalence of multidimensional differential systems [PDF]
arXiv, 2009 The bases of the theory of integrals for multidimensional differential systems are stated. The integral equivalence of total differential systems, linear homogeneous systems of partial differential equations, and Pfaff systems of equations is established.
arxiv
Advanced Science, EarlyView.This study verifies that circRNA‐mTOR exhibits high expression levels in HCC and has a strong correlation with patient prognosis. Mechanistically, circRNA‐mTOR achieves this effect by facilitating the nuclear translocation of RNA‐binding protein (RBP) PSIP1 through specific binding.
Yongchang Tang +12 more
wiley +1 more source