Results 131 to 140 of about 58,663 (324)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Effects of Temperature on CRISPR/Cas System [PDF]

, 2019
This project is part of the Meiothermus ruber genome analysis project, which uses a collection of online bioinformatics tools to predict gene function.
Beckom, Eddie, Scott, Dr. Lori
core   +1 more source

CRISPR/Cas-based nucleic acid detection strategies: Trends and challenges

Heliyon
CRISPR/Cas systems have become integral parts of nucleic acid detection apparatus and biosensors. Various CRISPR/Cas systems such as CRISPR/Cas9, CRISPR/Cas12, CRISPR/Cas13, CRISPR/Cas14 and CRISPR/Cas3 utilize different mechanisms to detect or ...
Jian Zhou, Zhuo Li, Joshua Seun Olajide, Gang Wang   +3 more
doaj  

In silico comparative analysis of crispr-cas system structures of Yersinia pseudotuberculosis causing different clinical manifestations of pseudotuberculosis

Журнал инфектологии, 2019
The aim of this research was to analyze and compare CRIPSR loci and cas-proteins of Yersinia pseudotuberculosis strains isolated in different territories from patients with various clinical manifestations of pseudotuberculosis.Materials and Methods ...
N. P. Peretolchina, Yu. P. Dzhioev, A. Yu. Borisenko, L. A. Stepanenko, E. A. Voskresenskaya, V. T. Klimov, O. N. Reva, V. I. Zlobin   +7 more
doaj   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

High-Throughput Screen Reveals sRNAs Regulating crRNA Biogenesis by Targeting CRISPR Leader to Repress Rho Termination [PDF]

, 2019
Discovery of CRISPR-Cas systems is one of paramount importance in the field of microbiology. Currently, how CRISPR-Cas systems are finely regulated remains to be defined.
Cheng, Zhenyu, Gao, Pan, Jiang, Jianxin, Lan, Lefu, Li, Guoping, Li, Rongpeng, Lin, Ping, Qin, Shugang, Schettler, Jacob, Wang, Biao, Wang, Zhihan, Wu, Min, Wu, Qinqin, Wu, Qun, Zhou, Chuanmin   +14 more
core   +1 more source

How the other half lives: CRISPR-Cas's influence on bacteriophages

, 2017
CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers.
AE Briner, AF Andersson, BR Levin, C Pourcel, CL Sun, D Bhaya, E Pennisi, E Scarpellini, EV Koonin, FS Berezovskaya, GW Tyson, H Deveau, H Deveau, I Yosef, IN Berezovsky, J He, J Iranzo, J Mahony, JF Heidelberg, JM Peters, JO Haerter, KD Seed, KL Maxwell, LA Marraffini, LM Childs, M Sebaihia, P Han, P Horvath, P Horvath, PD Hsu, R Barrangou, R Lillestøl, R Sorek, S Al-Attar, S Minot, W Jiang   +35 more
core   +1 more source

CRISPR/Cas-based screening of long non-coding RNAs (lncRNAs) in macrophages with an NF-κB reporter. [PDF]

, 2017
The innate immune system protects against infections by initiating an inducible inflammatory response. NF-κB is one of the critical transcription factors controlling this complex response, but some aspects of its regulation remain unclear.
Carpenter, Susan, Covarrubias, Sergio, Fong, Nicholas, Hanley, Nicole, Katzman, Sol, McManus, Michael T, Robinson, Elektra K, Shapleigh, Barbara, Vollmers, Apple   +8 more
core   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, Volume 8, Issue 7, July 2025.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Defense Systems Up: Structure of Subtype I-C/Dvulg CRISPR/Cas [PDF]

, 2012
N. LaRonde-LeBlanc
openalex   +1 more source