Results 171 to 180 of about 713,183 (311)

Copy Number Gains of VPS72 Drive De Novo Lipogenesis and Hepatocarcinogenesis via ATF3/mTORC1/SREBP1 Axis

Advanced Science, EarlyView.
VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang, Yunxing Huang, Yin Tong, Kenneth Tsz Chun Ng, Jiangwen Zhang   +4 more
wiley   +1 more source

Nonlinear Modal Decoupling of Multi-Oscillator Systems with Applications to Power Systems [PDF]

arXiv, 2016
Many natural and manmade dynamical systems that are modeled as large nonlinear multi-oscillator systems like power systems are hard to analyze. For such a system, we propose a nonlinear modal decoupling (NMD) approach inversely constructing as many decoupled nonlinear oscillators as the system oscillation modes so that individual decoupled oscillators ...
arxiv  

Defense Systems Up: Structure of Subtype I-C/Dvulg CRISPR/Cas [PDF]

, 2012
N. LaRonde-LeBlanc
openalex   +1 more source

Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury

Advanced Science, EarlyView.
Comprehensive epigenomic and transcriptomic profiling revealed a dynamic enhancer landscape and gene expression program associated with nephrolithiasis, highlighting RXRα as a central transcription factor in this regulatory network. Tubular‐specific deletion of RXRα increased intrarenal CaOx crystal deposition, while its activation with Bexarotene ...
Yu Yang, Xudan Dou, Yongzhan Sun, Mengyao Wang, Jing Wang, Xinyi Cao, Haijie Xie, Linguo Xie, Weiping Tian, Jing Nie, Yupeng Chen, Chunyu Liu, Lirong Zhang   +12 more
wiley   +1 more source

A bioinformatic approach to identify confirmed and probable CRISPR–Cas systems in the Acinetobacter calcoaceticus–Acinetobacter baumannii complex genomes

Frontiers in Microbiology
IntroductionThe Acinetobacter calcoaceticus–Acinetobacter baumannii complex, or Acb complex, consists of six species: Acinetobacter baumannii, Acinetobacter calcoaceticus, Acinetobacter nosocomialis, Acinetobacter pittii, Acinetobacter seifertii, and ...
Jetsi Mancilla-Rojano, Jetsi Mancilla-Rojano, Víctor Flores, Miguel A. Cevallos, Sara A. Ochoa, Julio Parra-Flores, José Arellano-Galindo, Juan Xicohtencatl-Cortes, Ariadnna Cruz-Córdova, Ariadnna Cruz-Córdova   +9 more
doaj   +1 more source

Chromosomal Targeting by the Type III-A CRISPR-Cas System Can Reshape Genomes in Staphylococcus aureus

mSphere, 2017
CRISPR-Cas (clustered regularly interspaced short palindromic repeat [CRISPR]-CRISPR-associated protein [Cas]) systems can provide protection against invading genetic elements by using CRISPR RNAs (crRNAs) as a guide to locate and degrade the target DNA.
Jing Guan, Wanying Wang, Baolin Sun
doaj   +1 more source

The Bacterial CRISPR/Cas System as Analog of the Mammalian Adaptive Immune System [PDF]

, 2012
Moran G. Goren, Ido Yosef, Rotem Edgar, Udi Qimron   +3 more
openalex   +1 more source

The CRISPR-Cas system

, 2020
Derived from and inspired by the adaptive immune system of bacteria, CRISPR has gone from basic biology knowledge to a revolutionizing biotechnological tool, applicable in many research areas such as medicine, industry and agriculture. The full mechanism of CRISPR-Cas9 was first published in 2012 and various CRISPR-Cas systems have already passed the ...
Stens, Cassandra, Enoksson, Isabella, Berggren, Sara   +2 more
openaire   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. [PDF]

, 2018
CRISPR-Cas systems provide microbes with adaptive immunity to infectious nucleic acids and are widely employed as genome editing tools. These tools use RNA-guided Cas proteins whose large size (950 to 1400 amino acids) has been considered essential to ...
Banfield, JF, Burstein, D, Chen, JS, Cofsky, JC, Doudna, JA, Harrington, LB, Kyrpides, NC, Ma, E, Paez-Espino, D, Witte, IP   +9 more
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