Results 251 to 260 of about 869,266 (345)

Deep learning in CRISPR-Cas systems: a review of recent studies. [PDF]

Front Bioeng Biotechnol, 2023
Lee M.
europepmc   +1 more source

Wogonin Attenuates Atherosclerosis via KLF11‐Mediated Suppression of PPARα‐YAP1‐Driven Glycolysis and Enhancement of ABCA1/G1‐Mediated Cholesterol Efflux

Advanced Science, EarlyView.
PPARα promotes KLF11 expression and recruits KLF11 and YAP1 to form a transcription complex, where KLF11 acts as a brake in PPARα‐YAP1‐mediated glycolysis. Wogonin reshapes the metabolism of macrophages from glycolysis to fatty acid oxidation via activation of the PPARα‐KLF11‐YAP1 pathway, by which wogonin reduces inflammation and foam cell formation ...
Chuanrui Ma, Yunqing Hua, Shu Yang, Yun Zhao, Wei Zhang, Yaodong Miao, Jing Zhang, Boxuan Feng, Guobin Zheng, Lan Li, Zhihao Liu, Han Zhang, Mingjun Zhu, Xiumei Gao, Guanwei Fan   +14 more
wiley   +1 more source

Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system

Heliyon
CRISPR-Cas, the adaptive immune system exclusive to prokaryotes, confers resistance against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited by scientists in a diverse range of genome editing applications.
Hui Cheng, Haoyue Deng, Dongdao Ma, Mengyuan Gao, Zhihan Zhou, Heng Li, Shejuan Liu, Tieshan Teng   +7 more
doaj  

Priming in a permissive type I-C CRISPR–Cas system reveals distinct dynamics of spacer acquisition and loss [PDF]

, 2017
Chitong Rao, Denny Chin, Alexander W. Ensminger   +2 more
openalex   +1 more source

Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling

Advanced Science, EarlyView.
This research presents a novel strategy employing the VGM cocktail, which combines HES7 overexpression with HDAC inhibitor and GABA, to enhance platelet production from hematopoietic stem and progenitor cells by promoting megakaryocyte progenitor (MkP) generation.
Huicong Liu, Lingna Wang, Jiaqing Liu, Haitao Yuan, Kaiqing Zhang, Yun Qiu, Fangfang Zhu   +6 more
wiley   +1 more source

Important applications of DNA nanotechnology combined with CRISPR/Cas systems in biotechnology. [PDF]

RSC Adv
Huang Y, Chen Z, Huang H, Ding S, Zhang M.   +4 more
europepmc   +1 more source

Comparative Genomic Analysis Identifies Divergent Genomic Features of Pathogenic Enterococcus cecorum Including a Type IC CRISPR-Cas System, a Capsule Locus, an epa-Like Locus, and Putative Host Tissue Binding Proteins

, 2015
Luke B. Borst, M. Mitsu Suyemoto, Elizabeth H. Scholl, Frederick J. Fuller, H. John Barnes   +4 more
openalex   +2 more sources

The driving force of prophages and CRISPR-Cas system in the evolution of Cronobacter sakazakii [PDF]

, 2017
Haiyan Zeng, Jumei Zhang, Chensi Li, Tengfei Xie, Na Ling, Qingping Wu, Yingwang Ye   +6 more
openalex   +1 more source

Recent Advances in Xenes Based FET for Biosensing Applications

Advanced Science, EarlyView.
Xenes (monoelemental 2D materials like graphene, phosphorene, tellurene) enable ultrasensitive FET (Field‐Effect Transistor) biosensors due to their tunable bandgap, high carrier mobility, and large surface area. Advances in synthesis (CVD, MBE) and functionalization allow detection of DNA/RNA (via CRISPR‐Cas systems), proteins, small molecules, and ...
Huide Wang, Chen Wang, Yule Zhang, Ziqian Wang, Yihan Zhu, Yun Wang, Xiangqian Hong, Han Zhang, Ning Fan, Meng Qiu   +9 more
wiley   +1 more source

HIV infection detection using CRISPR/Cas systems: Present and future prospects. [PDF]

Comput Struct Biotechnol J, 2023
Deng B, Xue J.
europepmc   +1 more source