Results 251 to 260 of about 38,793 (285)

CRISPR-Cas Systems: Bridging Bacterial Immunity and Host Interactions

Chinedu Eucharia Joseph, Aashika Jain, Muneer Oladipupo Yaqub, Lekshmi K. Edison   +3 more
openalex   +2 more sources

Characteristics and immune functions of the endogenous CRISPR-Cas systems in myxobacteria. [PDF]

mSystems
Hu W-f, Yang J-y, Wang J-j, Yuan S-f, Yue X-j, Zhang Z, Zhang Y-q, Meng J-y, Li Y-z.   +8 more
europepmc   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Repurposing endogenous type I-E CRISPR-Cas systems for natural product discovery in Streptomyces. [PDF]

Nat Commun
Zhou Q, Zhao Y, Ke C, Wang H, Gao S, Li H, Zhang Y, Ye Y, Luo Y.   +8 more
europepmc   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Advances in plant pathogen detection: integrating recombinase polymerase amplification with CRISPR/Cas systems. [PDF]

3 Biotech
Anbazhagan P, Parameswari B, Anitha K, Chaitra GV, Bajaru B, Rajashree A, Mangrauthia SK, Yousuf F, Chalam VC, Singh GP.   +9 more
europepmc   +1 more source

Dual Detection of Hepatitis B and C Viruses Using CRISPR-Cas Systems and Lateral Flow Assay. [PDF]

J Nucleic Acids
Shahni SN, Albogami S, Azmi I, Pattnaik B, Chaudhuri R, Dev K, Iqbal J, Sharma A, Ahmad T.   +8 more
europepmc   +1 more source

Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone. [PDF]

Genome Med
Jiang J, Cienfuegos-Gallet AV, Long T, Peirano G, Chu T, Pitout JDD, Kreiswirth BN, Chen L.   +7 more
europepmc   +1 more source

CRISPR-Cas Systems and Genome Editing: Beginning the Era of CRISPR/Cas Therapies for Humans. [PDF]

Int J Mol Sci
Karpov DS.
europepmc   +1 more source

Correction to 'DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems'. [PDF]

Nucleic Acids Res
europepmc   +1 more source