Results 271 to 280 of about 58,663 (324)

Effects of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein 9 system-Based Deletion of miR-451 in Mouse Embryonic Stem Cells on Their Self-Renewal and Hematopoietic Differentiation

, 2017
Su Jin Kim, Changhoon Kim, Borim An, Kwon‐Soo Ha, Seok-Ho Hong, Kye-Seong Kim   +5 more
openalex   +1 more source

CRISPR-Cas Systems Associated with Electrolyte-Gated Graphene-Based Transistors: How They Work and How to Combine Them. [PDF]

Biosensors (Basel)
Guermonprez P, Nioche P, Renaud L, Battaglini N, Sanaur S, Krejci E, Piro B.   +6 more
europepmc   +1 more source

Genetic Manipulation of Mammalian Cells in Microphysiological Hydrogels

Advanced Science, EarlyView.
Supply channels for cells embedded in gels can be used for in situ genetic manipulation. Abstract Engineering functional 3D tissue constructs is essential for developing advanced organ‐like systems, with applications ranging from fundamental biological research to drug testing. The generation of complex multicellular structures requires the integration
Anna C. Jäkel, Dong‐Jiunn Jeffery Truong, Friedrich C. Simmel   +2 more
wiley   +1 more source

Repurposing endogenous type I-E CRISPR-Cas systems for natural product discovery in Streptomyces. [PDF]

Nat Commun
Zhou Q, Zhao Y, Ke C, Wang H, Gao S, Li H, Zhang Y, Ye Y, Luo Y.   +8 more
europepmc   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

Characteristics and immune functions of the endogenous CRISPR-Cas systems in myxobacteria. [PDF]

mSystems
Hu W-f, Yang J-y, Wang J-j, Yuan S-f, Yue X-j, Zhang Z, Zhang Y-q, Meng J-y, Li Y-z.   +8 more
europepmc   +1 more source

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

Advanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu, Yu Liu, Junheng Zhang, Shuang Yang, Tianming Li, Haiqian Huang, Qian Liu, Hengliang Wang, Li Cao, Zhenghua An, Min Li, Hua Wang   +11 more
wiley   +1 more source

Impact of Virus‐Mediated Modifications in Bacterial Communities on the Accumulation of Soil Organic Carbon

Advanced Science, EarlyView.
This study illustrates the impact of viruses on carbon cycling in soils with different availabilities of carbon. In conditions of low carbon availability, viruses adopt a lysogenic lifestyle, integrate into the host genomes and facilitate the degradation of carbon.
Mingfeng Liu, Guixiang Zhou, Congzhi Zhang, Lin Chen, Donghao Ma, Lijun Zhang, Chunhua Jia, Ling Ma, Jiabao Zhang   +8 more
wiley   +1 more source

Role of CRISPR-Cas systems and anti-CRISPR proteins in bacterial antibiotic resistance. [PDF]

Heliyon
Kadkhoda H, Gholizadeh P, Samadi Kafil H, Ghotaslou R, Pirzadeh T, Ahangarzadeh Rezaee M, Nabizadeh E, Feizi H, Aghazadeh M.   +8 more
europepmc   +1 more source

Classification and Nomenclature of CRISPR-Cas Systems: Where from Here?

, 2018
Kira S. Makarova, Yuri I. Wolf, Eugene V. Koonin   +2 more
openalex   +1 more source