Results 101 to 110 of about 321,595 (358)

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds

Advanced Healthcare Materials, EarlyView.
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico, Irene Chiesa, Angela Toffano, Alessio Esposito, Piera Mancini, Chiara Magliaro, Angeliki Louvi, Carmelo De Maria, Marco Onorati   +8 more
wiley   +1 more source

274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency

Journal for ImmunoTherapy of Cancer, 2023
Sarah Cohen, Jacob Waldman, Andrew Dunn, Thao Nguyen, Jonathan Terrett, Brigid Mcewan, Meghna Kuppuraju, Mohammed Ghonime, Robert Chain, Zinkal Padalia, Demetrios Kalaitzidis, Elizabeth Koch, Lauren Zakas, Nivedita Jaishankar, Davis Settipane, Paul Tetteh, Mary-Lee Dequeant, Sushant Karnik, Chandirasegaran Massilamany, Henia Dar, Melanie Allen, Laura Serwer, Melanie Butler-Gauthier, Parin Sripakdeevong, Shashwat Nagar, Yin Tang, Nicole Flanagan, Elaine Huang, Shashwant Phuyal, Erisa Sula, Maria Lei Zhang, Cristian Loaiza, Erin Thorstensen, Keith Steiger, Katie Schum, Kayla Urbaez, Anna Ma, Annie Yang Weaver, Christopher Finch, PK Morrow, Mark Benton   +40 more
doaj   +1 more source

CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade

, 2020
Guangchuan Wang, Ryan D. Chow, Lvyun Zhu, Zhigang Bai, Lupeng Ye, Feifei Zhang, Paul Renauer, Matthew B. Dong, Xiaoyun Dai, Xiaoya Zhang, Yaying Du, Yujing Cheng, Leilei Niu, Zhiyuan Chu, Kristin Kim, Cun Liao, Paul Clark, Youssef Errami, Sidi Chen   +18 more
openalex   +2 more sources

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

324 Allogeneic CAR T cells targeting Liv-1 for breast cancer

Journal for ImmunoTherapy of Cancer, 2023
Minh Pham, Jonathan Terrett, Demetrios Kalaitzidis, Jason Sagert, Lauren Zakas, Laura Bartle, Zejun Li, Kelly Maeng, Luke Hanley, Avanti Ganpule   +9 more
doaj   +1 more source

Cationic nanocapsules as a non-viral vector for CRISPR-Cas9–based genome editing for myocilin associated glaucoma therapy

AIMS Molecular Science
Our aim of this work was the development of positively charged D-α-tocopheryl glycol succinate 1000 (TPGS)-chitosan nanocapsules (TCNs) as a non-viral vector for effective genome editing. A two-step process was used to create cationic TCNs.
Karthikeyan Kesavan, Virendra Kumar, Jothimani Rajeswari, Charles Searby, Val C. Sheffield   +4 more
doaj   +1 more source

Editing of the MALAT1 Gene in MDA-MB-361 Breast Cancer Cell Line using the Novel CRISPR Method

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2022
Introduction: Long non-coding RNAs play an important role in regulating gene expression, RNA processing, histone modification, and rearrangement of chromatin genes. These molecules can also be involved in many biological processes, such as organogenesis,
Soraya Ahmadi-Baloutaki, Abbas Doosti, mojtaba Jaafarinia, Hamedreza Goudarzi   +3 more
doaj  

Decision letter: Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations

, 2021
Steven Russell
openalex   +1 more source

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source