Results 111 to 120 of about 321,595 (358)

Genome editing from Cas9 to IscB: Backwards and forwards towards new breakthroughs

Engineering Microbiology, 2021
Zhenxiao Yu, Qunxin She
doaj   +1 more source

Abstract 1188: Codon Optimization of saCas9 Gene Enhances Protein Expression in Human Kidney Cells to Compensate for Difficulties in Delivery Vectors to Boost CRISPR-Cas9 in vivo Therapeutic Application

, 2023
Anoushka Krishnan, Zander Chierici, Dhruv Chinmay, Hannah Drew, Eli Cooper, Benjamin S. Cheng, Luke De, Paul Hauser   +7 more
openalex   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer [PDF]

, 2023
Dzana Dervovic, Ahmad Malik, Edward L.Y. Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni‐Zadeh, Dagmar Krenbek, Sébastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M. Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath K. Loganathan, Jongbok Lee, Li Zhang, Cynthia J. Guidos, Jeffrey L. Wrana, Arschang Valipour, Philippe P. Roux, Jüri Reimand, Hartland W. Jackson, Daniel Schramek   +24 more
openalex   +1 more source

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Science, 2018
Janice S. Chen, E. Ma, Lucas B. Harrington, Maria Da Costa, Xinran Tian, J. Palefsky, J. Doudna   +6 more
semanticscholar   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

CRISPR Inspirations [PDF]

Cell, 2018
openaire   +2 more sources

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source