Results 221 to 230 of about 321,595 (358)

CRISPR-Cas systems for editing, regulating and targeting genomes

Nature Biotechnology, 2014
Jeffry D. Sander, J. Joung
semanticscholar   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Near infrared light controlled gene editing. [PDF]

Light Sci Appl
Berezin MY.
europepmc   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Programmable molecular microscopy: CRISPR/Cas fluorescent probes revolutionizing spatiotemporal genomic imaging. [PDF]

Theranostics
Zhong XY, Yang YX, Xiong YF, Ye GC, Gong X, Zhong ML, He HD, Wang SG, Xia QD.   +8 more
europepmc   +1 more source

Generation of the Thr1857Met mutation in the mice by means of CRISPR-mediated HDR.

Juan A. De Pablo-Moreno (12300428), Leopoldo González-Brusi (3424271), Andrea Miguel-Batuecas (21464061), Pablo Bermejo-Álvarez (21464064), Luis Revuelta (3955946), Antonio Liras (12300431)   +5 more
openalex   +1 more source

Imagine CRISPR cures

Molecular Therapy, 2021
openaire   +2 more sources

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Disrupting Viral Persistence: CRISPR/Cas9-Based Strategies for Hepatitis B and C Treatment, and Challenges. [PDF]

J Cell Mol Med
Li MF, Zubair A, Wdidi S, He S.
europepmc   +1 more source

RNA targeting with CRISPR–Cas13

Nature, 2017
Omar O. Abudayyeh, J. Gootenberg, Patrick Essletzbichler, Shuo Han, J. Joung, Joseph J. Belanto, Vanessa Verdine, David B. T. Cox, M. Kellner, A. Regev, E. Lander, D. Voytas, A. Ting, Feng Zhang   +13 more
semanticscholar   +1 more source