Results 251 to 260 of about 333,510 (359)

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Construction of multi-targeted CRISPR libraries in tomato to overcome functional redundancy at genome-scale level. [PDF]

Nat Commun
Berman A, Su N, Li Z, Landau U, Chakraborty J, Gerbi N, Liu J, Qin Y, Yuan B, Wei W, Yanai O, Mayrose I, Zhang Y, Shani E.   +13 more
europepmc   +1 more source

LES CRISPRS, INSTRUMENTS D'ETUDE DE L'EVOLUTION INTER ET INTRA-SPÉCIFIQUE CHEZ LES MICROORGANISMES

, 2008
Ibtissem Grissa
openalex   +1 more source

CRISPR-Cas and restriction–modification systems are compatible and increase phage resistance [PDF]

, 2013
Marie-Ève Dupuis, Manuela Villion, Alfonso H. Magadán, Sylvain Moineau   +3 more
openalex   +1 more source

Getting Into the Rhythm With CRISPR [PDF]

Circulation Research, 2018
Thierry Vandendriessche, Marinee Chuah, Marinee Chuah   +2 more
openaire   +3 more sources

Model‐Guided Rational Construction of Escherichia coli Synthetic Consortia for Enhanced 2‐Methylbutyric Acid Production

Advanced Science, EarlyView.
We developed a citramalate‐derived pathway for 2‐methylbutyric acid production in E. coli mono‐culture and consortia. The optimized consortium, using 2‐keto‐3‐methylvalerate as a node, achieved 1817.03 ± 103.73 mg L−1 2‐methylbutyric acid, a 28‐fold increase from the initial strain, with a yield of 0.091 g/g glucose.
Yu Liu, Boyuan Xue, Shaojie Wang, Haijia Su   +3 more
wiley   +1 more source

AcrIE7 inhibits the CRISPR-Cas system by directly binding to the R-loop single-stranded DNA. [PDF]

Proc Natl Acad Sci U S A
Kim DY, Lee SY, Ha HJ, Park HH.
europepmc   +1 more source

Generating rats with conditional alleles using CRISPR/Cas9 [PDF]

, 2013
Yuanwu Ma, Xu Zhang, Bin Shen, Yingdong Lu, Wei Chen, Jing Ma, Lin Bai, Xingxu Huang, Lianfeng Zhang   +8 more
openalex   +1 more source

La Revolución CRISPR

, 2018
Grado en ...
openaire   +1 more source

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source