Results 281 to 290 of about 333,510 (359)
A Guide RNA Sequence Design Platform for the CRISPR/Cas9 System for Model Organism Genomes [PDF]
, 2013 Ming Ma +3 more
openalex +1 more source
Advanced Science, EarlyView.This work designs manganese metal‐organic frameworks (Mn‐MOFs) co‐assembled with Cas12a/crRNA, enabling rapid release of Mn2⁺ under mild conditions. The MOFs‐induced proximity effect sustains Mn2⁺‐Cas12a/crRNA interactions, enhancing the trans‐cleavage activity of complex available to develop an electrochemical biosensor based on Mn‐MOFs‐enhanced ...
Shuai Wu +8 more
wiley +1 more source
The potential of CRISPR-Cas9 in cardiovascular medicine: a focus on hereditary cardiomyopathies. [PDF]
Ann Med Surg (Lond)Rasheed S +8 more
europepmc +1 more source
Strong bias in the bacterial CRISPR elements that confer immunity to phage [PDF]
, 2013 David Páez-Espino +7 more
openalex +1 more source
Advanced Science, EarlyView.SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui +15 more
wiley +1 more source
Establishment of a Rapid Detection Technique Based on RPA-LFD and RPA-CRISPR/Cas12a on <i>Phytophthora pini</i>. [PDF]
MicroorganismsDai T, Guo Y, Wen T, Yu S, Tao Y, Liu Z.
europepmc +1 more source
Advanced Science, EarlyView.LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang +5 more
wiley +1 more source
A Label-Free CRISPR/Cas12a-G4 Biosensor Integrated with FTA Card for Detection of Foodborne Pathogens. [PDF]
Biosensors (Basel)Chao A, Hu Q, Yin K.
europepmc +1 more source
Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source