Results 281 to 290 of about 321,595 (358)

CRISPR-Cas Technology Turns <i>Chlamydomonas reinhardtii</i> into a Flagship for Algal Biotechnology. [PDF]

Mar Drugs
Antonacci A, Masi A, Vedi V, Colella S, Musella F, Fiorentino G, Scognamiglio V.   +6 more
europepmc   +1 more source

CRISPR genome editing using a combined positive and negative selection system

Ishrya Sharma, Kelly Hall, Shannon Moonah   +2 more
openalex   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Therapeutic applications of CRISPR-Cas9 gene editing. [PDF]

Front Genome Ed
Bharti A, Mudge J.
europepmc   +1 more source

A Review of Gene Editing Technologies in Poultry Breeding: Focus on CRISPR/Cas9

Yanlin Wang, QiQi Zhou, Jia Chen
openalex   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Rapid and Simple Detection of <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> Using a Lateral Flow Assay Based on CRISPR-Cas12a Combined with Recombinase Polymerase Amplification or Nested PCR. [PDF]

Pathogens
Lv YR, Liu YY, Zhang R, Yang B, Xue SY, Ding YL, Jia JT, Bayaer H, Bagen A, Chen RB, Tunala S, Zhao L, Liu YH.   +12 more
europepmc   +1 more source

Crispr-Based Gene Editing: Ethical Considerations and Future Prospects in Medicine

Anoop Dev, Sidhant Das, Ezhilarasan Ganesan, Shivangi Gupta, S. N. Upadhyay, Chinmaya Kumar Mohapatra, M. Abilasha   +6 more
openalex   +2 more sources

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

CRISPR-Cas12a-based lateral flow detection of white spot syndrome virus: a dual-target approach for detection of early and latent infection. [PDF]

J Vet Diagn Invest
Manojkumar C, Limbola M, Paul S, Thangadurai K, Rajendran KV, Roy A, Mandal B, Jeena K, Bedekar MK.   +8 more
europepmc   +1 more source