Results 41 to 50 of about 2,262,136 (302)

Effestiveness and efficiency criteria for strategic application of mechatronics in business processes

open access: yesInsights into Regional Development, 2021
The present paper is centred on the effects of mechatronics in both high-tech and technologically less intensive firms. The strategy of innovation implementation in the mechatronics industry is tackled from both the high-tech business development ...
Mindaugas Laužikas   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Rapid decay in the relative efficiency of quarantine to halt epidemics in networks

open access: yes, 2017
Several recent studies have tackled the issue of optimal network immunization by providing efficient criteria to identify key nodes to be removed in order to break apart a network, thus preventing the occurrence of extensive epidemic outbreaks.
Castellano, Claudio, Strona, Giovanni
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

CRITERIA OF TUBERCULOSIS TREATMENT EFFICIENCY IN CHILDREN UNDER CURRENT CONDITIONS

open access: yesТуберкулез и болезни лёгких, 2017
The main objective of a phthisiologist following up and treating children and adolescents with local forms of tuberculosis is to achieve complete clinical cure with minimal remaining post-tuberculosis changes.
N. A. Barmina   +4 more
doaj   +1 more source

Exploiting Trade-Off Criteria to Improve the Efficiency of Genetic Multi-Objective Optimisation Algorithms

open access: yesFrontiers in Chemical Engineering, 2021
The highly competitive nature of the chemical industry requires the optimisation of the design and exploitation of (bio-)chemical processes with respect to multiple, often conflicting objectives. Genetic algorithms are widely used in the context of multi-
Viviane De Buck   +4 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Comparison of different efficiency criteria for hydrological model assessment [PDF]

open access: yesAdvances in Geosciences, 2005
The evaluation of hydrologic model behaviour and performance is commonly made and reported through comparisons of simulated and observed variables. Frequently, comparisons are made between simulated and measured streamflow at the catchment outlet.
P. Krause, D. P. Boyle, F. Bäse
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Разработка комплексных показателей экономической эффективности управления предпринимательскими структурами

open access: yesПутеводитель предпринимателя, 2020
This paper addresses the problem of assessing the economic efficiency of management, when there is a need to find domestic sources for growth of business structures.

doaj  

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