Results 61 to 70 of about 229,715 (264)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Strength criterion of composite solid propellants under dynamic loading

open access: yesDefence Technology, 2018
Based on the dynamic loading (1-100 s−1) experiments under different temperatures (223–298 K) and stress states, uniaxial and biaxial strength criterion of a Hydroxyl-terminated polybutadiene (HTPB) based composite solid propellant were further ...
Zhe-jun Wang   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Bimodal strength criterion and constitutive model for cemented sand and gravel

open access: yesYantu gongcheng xuebao
In order to explore the intricate mechanical properties of the cemented sand and gravel (CSG), large-scale triaxial shear tests are conducted on the specimens with varying confining pressures and gel contents.
WU Yingli 1 , REN Honglei 1, 2, GUO Wanli 1
doaj   +1 more source

Influence of Rock Properties in Estimating Rock Strength for Shallow Underground Structures in Weak Rocks

open access: yesIndonesian Journal on Geoscience, 2018
DOI: 10.17014/ijog.5.2.93-105Two popular rock strength criteria, the linear Coulomb and non-linear Hoek-Brown, are widely used in underground designs. These two criteria may be applied differently depending on rock conditions.
Didi Supriadi Agustawijaya
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

The Influence of Rock Properties and Size into Strength Criteria: A Proposed Criterion for Soft Rock Masses

open access: yesCivil Engineering Dimension, 2011
A new modified strength criterion for soft rock masses is proposed in this paper in order to provide a suitable estimation for soft rock mass strength.
Agustawijaya D.S.
doaj  

Prediction Ability Analysis of Phenomenological Strength Criteria for Composites

open access: yesЖурнал інженерних наук
The article examines and assesses the phenomenological strength theory of composite materials. A comparative analysis of the theoretical envelopes was conducted for each criterion. A unified form of the phenomenological strength criterion was established.
Huang T.
doaj   +1 more source

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