Results 81 to 90 of about 1,101,663 (283)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Modified criterion for prediction of tunnel deformation in non-squeezing ground conditions

Journal of Modern Transportation, 2018
The strength factor-based criterion for tunnel deformation prediction proposed by Hoek in 2000 is reckoned to be the most practical criterion among the tunnel deformation criteria since 1980s.
Ako Daraei, Shokrollah Zare
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Temperature-dependent yield criterion for high strength steel sheets under warm-forming conditions

MATEC Web of Conferences, 2015
In this paper, uniaxial and biaxial tensile tests with cruciform specimens were conducted to investigate the deformation behaviour of dual phase steel sheet with a tensile strength of 590 MPa (DP590) under evaluated warm-forming temperatures (20–190 ∘C).
Cai Zhengyang, Diao Keshan, Wu Xiangdong, Wan Min, Cheng Cheng   +4 more
doaj   +1 more source

Modeling of Eyld2000-2d Anisotropic Yield Criterion Considering Strength Differential Effect and Analysis of Optimal Calibration Strategy. [PDF]

Materials (Basel), 2023
Du K, Dong L, Zhang H, Mu Z, Dong H, Wang H, Ren Y, Sun L, Zhang L, Yuan X.   +9 more
europepmc   +1 more source

Plane-stress fracture of compact and notch-bend specimens [PDF]

Thin-gaged or high toughness materials containing cracks usually fail in a ductile manner with nominal failure stresses approaching the ultimate strength of the material. For such materials, a two-parameter fracture criterion was developed.
Newman, J. C., Jr.
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Triaxial strength behaviour of rockmass satisfying Modified Mohr-Coulomb and Generalized Hoek-Brown criteria

International Journal of Mining Science and Technology, 2018
The triaxial strength of twenty rockmass types was predicted using two non-linear triaxial strength criteria for rockmass i.e. Modified Mohr-Coulomb (MMC) criterion and Generalized Hoek-Brown (GHB) criterion.
Saurav Rukhaiyar, Narendra Kumar Samadhiya   +1 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source