Results 101 to 110 of about 1,101,663 (283)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Diffusion bonding of IN 718 to VM 350 grade maraging steel [PDF]

, 1972
Diffusion bonding studies have been conducted on IN 718, VM 350 and the dissimilar alloy couple, IN 718 to maraging steel. The experimental processing parameters critical to obtaining consistently good diffusion bonds between IN 718 and VM 350 were ...
Biederman, R. R., Crosby, S. R., Reynolds, C. C.   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Influence of Rock Properties and Size into Strength Criteria: A Proposed Criterion for Soft Rock Masses

Civil Engineering Dimension, 2011
A new modified strength criterion for soft rock masses is proposed in this paper in order to provide a suitable estimation for soft rock mass strength.
Agustawijaya D.S.
doaj  

Bimodal strength criterion and constitutive model for cemented sand and gravel

Yantu gongcheng xuebao
In order to explore the intricate mechanical properties of the cemented sand and gravel (CSG), large-scale triaxial shear tests are conducted on the specimens with varying confining pressures and gel contents.
WU Yingli 1 , REN Honglei 1, 2, GUO Wanli 1
doaj   +1 more source

Strength criterion of composite solid propellants under dynamic loading

Defence Technology, 2018
Based on the dynamic loading (1-100 s−1) experiments under different temperatures (223–298 K) and stress states, uniaxial and biaxial strength criterion of a Hydroxyl-terminated polybutadiene (HTPB) based composite solid propellant were further ...
Zhe-jun Wang, Hong-fu Qiang, Guang Wang, Biao Geng   +3 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Structure of the confining solutions for SU(3)-Yang-Mills equations and confinement mechanism

, 2005
Structure of exact solutions modelling confinement is discussed for SU(3)-Yang-Mills equations and uniqueness of such confining solutions is proved in a certain sense.
Bander, Barut, Berestezkiy, Besse, Bochkarev, Cartan, Eidelman, Finster, Finster, Goncharov, Goncharov, Goncharov, Goncharov, Lawson, Postnikov, Ryder, Savel'ev, Sokolov, Wilson, Yu.P. Goncharov   +19 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Prediction Ability Analysis of Phenomenological Strength Criteria for Composites

Журнал інженерних наук
The article examines and assesses the phenomenological strength theory of composite materials. A comparative analysis of the theoretical envelopes was conducted for each criterion. A unified form of the phenomenological strength criterion was established.
Huang T.
doaj   +1 more source