Results 61 to 70 of about 1,576,250 (293)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

An entropy criterion for the validity of Navier-Stokes order continuum theory for gas-solid flow: Kinetic theory analysis

open access: yes, 2017
Navier-Stokes order continuum theory (NS theory) established on the basis of local thermodynamic equilibrium (LTE) postulate has been widely used to study gas-solid flows.
Zhao, Bidan, Wang, Jing, Wang, Junwu
core   +1 more source

Improving the Measurement of Older Adults’ Mobile Device Proficiency: Results and Implications from a Study of Older Adult Smartphone Users

open access: yesIEEE Access, 2019
Mobile device (e.g., smartphone) proficiency is becoming increasingly necessary to perform important everyday tasks, and inadequate proficiency can prevent groups of individuals such as older adults from obtaining the benefits of mobile computing and ...
Andraz Petrovcic   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

上肢动作研究测试量表评定亚急性期缺血性卒中患者偏瘫侧上肢及手功能的信效度和敏感性研究 (Study on the Reliability, Validity, and Sensitivity of Action Research Arm Test Scale in Evaluating the Function of Hemiplegic Upper Limb and Hand in Subacute Stage Ischemic Stroke Patients)

open access: yesZhongguo cuzhong zazhi
目的 探讨上肢动作研究测试(action research arm test,ARAT)量表应用于亚急性期缺血性卒中患者上肢及手功能障碍评定的效度、信度和敏感性。 方法 本研究招募2020年1月—2022年5月于首都医科大学附属北京天坛医院等17家医院住院的300例缺血性卒中患者,并由两名评定者分别对受试者进行ARAT量表评估。同时以Fugl-Meyer运动功能评定量表上肢部分(Fugl-Meyer assessment-upper extremity,FMA-UE ...
吴娱倩1,张玉梅1,臧大维1,2,3,范小伟4,王安心2,3,张晓丽2,3,孟霞2,3 (WU Yuqian1, ZHANG Yumei1, ZANG Dawei1,2,3, FAN Xiaowei4, WANG Anxin2,3, ZHANG Xiaoli2,3, MENG Xia2,3 )
doaj   +1 more source

A New Asymmetric Criterion for Cluster Validation [PDF]

open access: yes, 2011
In this paper a new criterion for clusters validation is proposed. Many stability measures to validate a cluster have been proposed such as Normalized Mutual Information. We propose a new criterion for clusters validation. The drawback of the common approach is discussed in this paper and then a new asymmetric criterion is proposed to assess the ...
Hosein Alizadeh   +2 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Reliability, criterion-concurrent validity, and construct-discriminant validity of a head-marking version of the taekwondo anaerobic intermittent kick test

open access: yes, 2021
This study aimed to examine the reliability and validity of a head-marking version of the taekwondo anaerobic intermittent kick test (TAIKT-head). Twenty-seven (21 males and 6 females) taekwondo athletes performed TAIKT-head on two occasions (test-retest)
Anis Chaouachi   +6 more
core   +1 more source

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