Results 91 to 100 of about 15,560,638 (291)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Errores de conciencia situacional. 200 casos de incidentes críticos en anestesia y cuidados intensivos.

open access: yesRevista Electrónica de AnestesiaR, 2018
El análisis de la conciencia situacional supone un abordaje prometedor para mejorar nuestro conocimiento sobre el desarrollo de los errores humanos en los sistemas de salud.
Jorge Becerra Astaiza   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

HIGHER EDUCATED PEOPLE AND (RE)EMPLOYMENT PROBABILITY IN ROMANIA [PDF]

open access: yesAnnals of the University of Craiova: Economic Sciences Series, 2017
The aim of this research is to analyze the (re)employment probability of long-term university graduates registered as unemployed at the National Agency of Employment Romania.
Daniela-Emanuela Dănăcică
doaj  

Move Beyond the Text

open access: yesActa Universitatis Lodziensis: Kształcenie Polonistyczne Cudzoziemców, 2017
Reading is a complex skill which is indispensable in order to be successful in pursuing a scientific career. While reading specialist texts, it is necessary to go through the literal, inferential and creative-evaluative levels of comprehension.
Urszula Swoboda-Rydz
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Pemikiran Kritis Abu Zaid Terhadap Wacana Keagamaan: Implikasinya Dalam Pengembangan Pembelajaran Teologi di PTAI

open access: yesINSANIA: Jurnal Pemikiran Alternatif Kependidikan, 2015
: Abu Zaid finds that all religious thoughts have been tightly affected by social, cultural, economic, and political interests and tendencies until there are so many difficulties to differentiate between the essence of Islamic doctrines and their ...
suparjo suparjo
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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