Results 111 to 120 of about 15,560,638 (291)
Critical care in Latin America: current situation
, 2006 At the beginning of this new millennium it was the 50th anniversary of critical care created as a new medical specialty. Bjorn Ibsen started in Copenhagen in 1952 what can today be said to be the first ICU, set up to provide ventilation support to ...
Celis-Rodríguez, Edgar, Rubiano, Sandra
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2015 CESCA is now on Twitter. If you have a twitter account, we invite you to follow us! If do you do not have a twitter account, you may still view our news feeds on twitter.com/vt_cesca . We plan to make regular updates on twitter.
Virginia Tech. Center for Embedded Systems for Critical Applications
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Celebrating unusual events: Initiating a critical discourse
, 2023 The number and variety of events which are staged around the world is staggering and there are no signs of abatement. Several categorizations have been presented which cluster events into coherent groupings based on type, as in what happens at the event,
Arcodia, Charles, Le, Truc
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Other title: At head of title: Kansas Department of Transportation; Other title: Final Report
, 2017 application/pdf; "July 6, 2017."; "This copy contains only the Executive Summary portion of the report.""On March 21, 2016, the Kansas Department of Administration, Office of Procurement and Contracts, issued Request for Proposal (RFP) Bid Event ...
Mission Critical Partners, Inc.
core
Nurses' perceived barriers and educational needs for early mobilisation of critical ill patients
, 2019 BACKGROUND: Early mobilisation (EM) of critically ill patients is an evidence-based intervention designed to improve treatment outcomes and enhance the quality of life after intensive care.
최모나, 김상희
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source