Results 121 to 130 of about 7,934,690 (311)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
, 2013 The Full, uninterrupted first issue of Criticial Intersections in ...
Intersections, Critical
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
, 2009 More than any other textbook, Moore and Parker's Critical Thinking has defined the structure and content of the critical thinking course at colleges and universities across the country--and has done so with a witty writing style that students enjoy ...
Moore, Brooke Noel, Parker, Richard
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Automated identification of safety-critical attacks against CPS and generation of assurance case fragments [PDF]
Ensuring the safety of cyber-physical systems (CPS) against cyber security threats is essential in safety-critical sectors. To this end, the systematic derivation of clear and robust safety claims is needed to demonstrate that safety properties are ...
Guerra, Sofia +2 more
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A Handbook of Critical Approaches to Literature [PDF]
, 1999 xvi.395 hal.;23 ...
A Handbook of Critical Approaches to Literature
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
LA ENSAYÍSTICA DE MARTÍN CERDA
Universum, 2010 El propósito de este trabajo es realizar un rastreo y precisión de las categorías ensayísticas de Martín Cerda (1930-1991). Se sabe que escribió más de cuatro mil fragmentos y algunos libros completos que se quemaron en su residencia de la Universidad de
José Alberto de la Fuente
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