Results 51 to 60 of about 4,960,171 (291)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Golgi pH homeostasis stabilizes the lysosomal membrane through N -glycosylation of membrane proteins
Life Science AllianceGolgi pH imbalance ( Gphr deficiency) disrupts lysosomal membrane protein glycosylation, compromising lysosomal membrane stability, highlighting the critical role of the Golgi apparatus.
Yu-shin Sou +5 more
doaj +1 more source
Racial Profiling and Moral Panic: Operation Thread and the Al-Qaeda Sleeper Cell that Never Was [PDF]
Global Media Journal: Canadian Edition, 2009 In August 2003, Canadian and international media broke news of Operation Thread, executed by the Canadian state security apparatus to apprehend 23 South-Asian Muslim members of a “possible Al-Qaeda sleeper cell” in the Greater Toronto Area.
Felix Odartey-Wellington
doaj
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Weak Interactions between Salmonella enterica FlhB and Other Flagellar Export Apparatus Proteins Govern Type III Secretion Dynamics. [PDF]
PLoS ONE, 2015 The bacterial flagellum contains its own type III secretion apparatus that coordinates protein export with assembly at the distal end. While many interactions among export apparatus proteins have been reported, few have been examined with respect to the ...
Jonathan L McMurry +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Doing Re-Enacting. Invisible Gestures of Protest. An Interview with Barbora Klímová [PDF]
, 2020 Sandra Frimmel`s and Kata Krasznahorkai`s interview with Barbora ...
Frimmel, Sandra; https://orcid.org/ +2 more
core +1 more source
Verification of a novel stress path method by true-triaxial test
Scientific ReportsTo verify the novel method of achieving a true-triaxial stress path with the pseudo-triaxial apparatus, a series of drained and undrained tests were carried out for the identical scheme with pseudo-triaxial apparatus and true-triaxial apparatus ...
Zhigang Ma, Xuefeng Li, Longlong Lv
doaj +1 more source