Results 111 to 120 of about 6,330 (199)

Balancing Exploration and Exploitation Through a Sequential Hybrid of Roach Infestation and Mayfly Algorithms for Constrained Engineering Design Optimization

open access: yesAI &Innovation, EarlyView.
ABSTRACT Maintaining an effective balance between exploration and exploitation is essential during optimization processes, from mathematical functions to more complex problems such as constrained engineering design optimization, particularly when addressing highly nonlinear issues with numerous local optima and strict feasibility requirements.
Enrique Lizárraga   +3 more
wiley   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

open access: yesAnnals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato   +7 more
wiley   +1 more source

Initiating Market Formation Through Local Policy Innovation: Plot Handover as a Driver for Circular Construction

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT The transition to circular construction suffers from uncertainties related to costs, market realities, supply, regulations and expertise using secondary materials in building projects. Uncertainties are large, and resolving them needs policy interventions.
Erkki‐Jussi Nylén, Tommi Halonen
wiley   +1 more source

Modular Assembly of a Biocatalytic Material for Stereoselective C─Si Bond Formation

open access: yesChemistry – A European Journal, EarlyView.
A modular, carrier‐free enzyme foam derived from Rhodothermus marinus cytochrome c combines structural stability with catalytic efficiency for stereoselective C─Si bond formation. Streptavidin (STV)‐mediated protein crosslinking creates a robust, self‐supporting materials platform for next‐generation biocatalysis.
Marc F. Münker   +6 more
wiley   +1 more source

New Insights Into the Three‐Dimensional Mechanics of the Flagellar Beat Cycle

open access: yesCytoskeleton, EarlyView.
ABSTRACT Advances in imaging at the molecular scale have provided greater detail concerning the three‐dimensional structure of the ciliary/flagellar axoneme. Additionally, it has recently been confirmed that electrostatic forces regulate the dynein‐tubulin interaction at the microtubule binding domain (MTBD) of dynein, and at the junction of the nexin ...
Charles B. Lindemann
wiley   +1 more source

Multi‐factor coupling effects in hydraulic fracturing of laminated shale: Experimental insights and physics‐informed neural network‐driven optimization

open access: yesDeep Underground Science and Engineering, EarlyView.
This study establishes a multi‐factor coupling framework for predicting breakdown pressure in laminated shale by integrating experimental hydraulic fracturing tests, physics‐informed neural networks (PINNs), and Sobol sensitivity analysis. It reveals how differential stress, the bedding dip angle, and the injection rate interact to influence fracture ...
Tao Wang   +6 more
wiley   +1 more source

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