Results 71 to 80 of about 804,475 (313)

Critical (Intensive) Care Medicine and CPRA Personal History ByMax Harry Weil

open access: yesSigna Vitae, 2010
I perceive that the most consitent pursuits of successful innovators and leaders in medicine, as in all endeavors, come from aspirations generated by dreams rather than hope or by fate alone; from the excitement with which the dreamer atracts collaborators who have prepared minds and skillful hands; they join talents and destinities to convert the ...
openaire   +4 more sources

Parents’ and carers’ experiences of transition and aftercare following a child's discharge from a paediatric intensive care unit to an in-patient ward setting:A qualitative systematic review [PDF]

open access: yes, 2019
Objectives: To explore parents’ experiences of transition and aftercare following their child’s discharge from a pediatric intensive care unit to an inpatient ward.Methods: A qualitative systematic review was conducted.
Evans, Catrin   +2 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Satisfaction with quality of ICU care for patients and families: the euroQ2 project

open access: yesCritical Care, 2017
Background Families’ perspectives are of great importance in evaluating quality of care in the intensive care unit (ICU). This Danish-Dutch study tested a European adaptation of the “Family Satisfaction in the ICU” (euroFS-ICU).
Hanne Irene Jensen   +8 more
doaj   +1 more source

The intensive care medicine clinical research agenda in paediatrics [PDF]

open access: yes, 2017
BACKGROUND: Intensive Care Medicine set us the task of outlining a global clinical research agenda for paediatric intensive care (PIC). In line with the clinical focus of this journal, we have limited this to research that may directly influence ...
Argent, A   +9 more
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

2378 Addressing challenges from missing data in a global quality improvement study

open access: yesJournal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Missing data is a common problem in research studies that may lead to inconclusive or inaccurate results. It may even lead to harm secondary to wrong research conclusions.
Amelia Barwise   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Acute Care Study Explores Link Between Tracheostomy and Long-Term Outcomes of Critically Ill Patients [PDF]

open access: yes, 2015
Tracheostomy – placement of a tube through an incision in the trachea, or windpipe – is routinely performed on a variety of patients in Medical Intensive Care Units (MICUs) and Surgical Intensive Care Units (SICUs). “Trach” patients may include those who

core   +1 more source

Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit [PDF]

open access: yes, 2002
INTRODUCTION: The diagnosis of sepsis in critically ill patients is challenging because traditional markers of infection are often misleading. The present study was conducted to determine the procalcitonin level at early diagnosis (and differentiation ...
BalcI, Canan   +4 more
core   +2 more sources

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