Results 81 to 90 of about 895,229 (373)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Analysis of Difficult Tracheal Intubation Based on Video Records Using a Macintosh Type Video Intubating Laryngoscope in Adult [PDF]

, 2005
To assess the incidence of the difficult intubation and evaluate its clinical characteristics, we analyzed 964 cases of video records of tracheal intubation by Macintosh type video laryngoscope (MVL; X-Lite video^[○!R]: Rusch, Germany).
Division of Anesthesia, Department of Intensive and Critical Care Medicine, Dokkyo University School of Medicine, Division of Anesthesia, Department of Intensive and Critical Care Medicine, Dokkyo University School of Medicine, Hisao Matsushima, Yoshinori Iwase   +3 more
core   +1 more source

Thrombin Generation and Platelet Function in ICU Patients Undergoing CVVHD Using Regional Citrate Anticoagulation

Frontiers in Medicine, 2021
Background: To investigate pro- and anticoagulant alterations in uremic critically ill patients prior to and during continuous renal replacement therapy.
Marion Wiegele, Lukas Infanger, Conrad Lacom, Stefan Koch, Andreas Baierl, Eva Schaden   +5 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Risk factors for in-hospital mortality in older patients with acute respiratory distress syndrome due to COVID-19: a retrospective cohort study

BMC Geriatrics
Background Advancing age is associated with an increase in mortality among patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19).
David Rene Rodriguez Lima, Jimmy Hadid Anzueta Duarte, Cristhian Rubio Ramos, Laura Otálora González, Darío Isaías Pinilla Rojas, Leonardo Andrés Gómez Cortés, Edith Elianna Rodríguez Aparicio, Andrés Felipe Yepes Velasco, German Devia Jaramillo   +8 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Helmet noninvasive support for acute hypoxemic respiratory failure: rationale, mechanism of action and bedside application

Annals of Intensive Care, 2022
Introduction Helmet noninvasive support may provide advantages over other noninvasive oxygenation strategies in the management of acute hypoxemic respiratory failure.
Melania Cesarano, Domenico Luca Grieco, Teresa Michi, Laveena Munshi, Luca S. Menga, Luca Delle Cese, Ersilia Ruggiero, Tommaso Rosà, Daniele Natalini, Michael C. Sklar, Salvatore L. Cutuli, Filippo Bongiovanni, Gennaro De Pascale, Bruno L. Ferreyro, Ewan C. Goligher, Massimo Antonelli   +15 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

ICU-acquired pneumonia is associated with poor health post-COVID-19 syndrome [PDF]

, 2021
Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about
Ceccato, Adrián, Fernández Barat, Laia, Gabarrús, Albert, Garcia Gasulla, Dario, González Gutiérrez, Jessica, Martin Loeches, Ignacio, Menéndez Villanueva, Rosario, Motos Galera, Ana, Pérez Arnal, Raquel Leandra   +8 more
core   +1 more source

The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?

Critical Care, 2021
There is ongoing demographic ageing and increasing longevity of the population, with previously devastating and often-fatal diseases now transformed into chronic conditions.
M. Beil, H. Flaatten, B. Guidet, S. Sviri, C. Jung, D. D. de Lange, S. Leaver, J. Fjølner, W. Szczeklik, P. V. van Heerden   +9 more
semanticscholar   +1 more source