Results 81 to 90 of about 804,475 (313)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Association between continuous hyperosmolar therapy and survival in patients with traumatic brain injury – a multicentre prospective cohort study and systematic review

Critical Care, 2017
Background Intracranial hypertension (ICH) is a major cause of death after traumatic brain injury (TBI). Continuous hyperosmolar therapy (CHT) has been proposed for the treatment of ICH, but its effectiveness is controversial.
Karim Asehnoune, Sigismond Lasocki, Philippe Seguin, Thomas Geeraerts, Pierre François Perrigault, Claire Dahyot-Fizelier, Catherine Paugam Burtz, Fabrice Cook, Dominique Demeure dit latte, Raphael Cinotti, Pierre Joachim Mahe, Camille Fortuit, Romain Pirracchio, Fanny Feuillet, Véronique Sébille, Antoine Roquilly, For the ATLANREA group, For the COBI group   +17 more
doaj   +1 more source

A readers' guide to the interpretation of diagnostic test properties: clinical example of sepsis [PDF]

, 2018
Background: One of the most challenging practical and daily problems in intensive care medicine is the interpretation of the results from diagnostic tests.
Bachmann, Lucas, Fischer, Joachim, Jaeschke, Roman   +2 more
core  

Pioneering contributions of Peter Safar to intensive care and the founding of the Society of Critical Care Medicine

Critical Care Medicine, 2004
During the Crimean War, Florence Nightingale, the parent of professional nursing, segregated the most severely injured soldiers and bedded them in close proximity to the nursing station. This perhaps represented the beginning of intensive care.
Max Harry, Weil, William C, Shoemaker
openaire   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Intelligent decision support in Intensive Care : towards technology acceptance [PDF]

, 2012
Decision support technology acceptance is a critical factor in the success of the adoption this type of systems by the users. INTCARE is an intelligent decision support system for intensive care medicine.
Abelha, António, Machado, José Manuel, Neves, José, Portela, Filipe, Rua, Fernando, Santos, Manuel Filipe, Silva, Álvaro   +6 more
core  

Prevention of acute kidney injury and protection of renal function in the intensive care unit : update 2017 [PDF]

, 2017
Background: Acute kidney injury (AKI) in the intensive care unit is associated with significant mortality and morbidity. Objectives: To determine and update previous recommendations for the prevention of AKI, specifically the role of fluids, diuretics ...
Druml, W, Forni, LG, Groeneveld, ABJ, Honore, PM, Hoste, Eric, Joannidis, M, Ostermann, M, Oudemans-van Straaten, HM, Schetz, Mathias   +8 more
core   +3 more sources

Intensive Care Unit Rotations and Predictors of Career Choice in Pulmonary/Critical Care Medicine: A Survey of Internal Medicine Residency Directors

Critical Care Research and Practice, 2018
Background. The United States (US) is experiencing a growing shortage of critical care medicine (CCM) trained physicians. Little is known about the exposures to CCM experienced by internal medicine (IM) residents or factors that may influence their decision to pursue a career in pulmonary/critical care medicine (PCCM). Methods. We conducted a survey of
Daniel J. Minter, Sean D. Levy, Sowmya R. Rao, Paul F. Currier   +3 more
openaire   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

ACCCN Workforce Standards for Intensive Care Nursing: Systematic and evidence review, development, and appraisal [PDF]

, 2017
Background: The intensive care nursing workforce plays an essential role in the achievement of positive healthcare outcomes. A growing body of evidence indicates that inadequate nurse staffing and poor skill mix are associated with negative outcomes for ...
Chamberlain, Diane, Fulbrook, Paul, Pollock, Wendy   +2 more
core   +3 more sources