Results 101 to 110 of about 3,145,854 (263)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Territories of scarcity and creativity: a critical view of informal settlements and emerging tactics under conditions of scarcity in Nairobi, Kenya and Quito, Ecuador [PDF]
, 2014 This thesis explores the processes through which scarcity is constructed in informal settlements and how conditions emerging within its limits gives way to particular socio-spatial phenomena and influence the emergence of self-organisation and creative ...
Nunez Ferrera, Isis
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The Conditions of Possibility of Critical Psychology
, 2010 I argue for an approach to critical psychology that is strongly foundationalist and radically anti-fundamentalist. By laying foundations for psychology in the historical and social conditions of its subject matter, the paper works against the ...
Gordana Jovanović
core +1 more source
Rate-induced critical transitions [PDF]
, 2020 This thesis focuses on rate-induced critical transitions or tipping points (R-tipping points), where the system undergoes a critical transition if the time-varying external conditions vary faster than some critical rate.
Xie, Chun
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Possible alternatives to critical elements in coatings for extreme applications
, 2018 Surface functionalisation and protection have been used since a long time for improving specific properties of materials such as lubrication, water repellence, brightness, and for increasing durability of objects and tools.
Grilli, M.L. +3 more
core +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Galloping critical conditions on yawed square cylinders
, 2010 This paper concerns the study of galloping critical conditions on square cylinders having an arbitrary attitude in the wind flow. It is based on a consistent theoretical model of wind actions which permits the analysis of a generic-shaped cross-section ...
FREDA, ANDREA +2 more
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