Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Critical literacy : the Four Resources model & (teaching) reading
, 2019 Reading, from a critical literacy perspective, requires that teachers and learners make meaning beyond the text: from decoding, to comprehension, to critical language awareness. Where decoding is related to the technical skills of reading (linking sounds
Govender, Navan
core +2 more sources
Risk factors of developing critical conditions in Iranian patients with COVID-19. [PDF]
Glob Epidemiol, 2021 Arman A +7 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Success of Succinates and Prospects for Their Use in Critical Conditions
Антибиотики и ХимиотерапияTo date, preparations containing succinic acid (succinate) are widely known to specialists working in intensive care. Several such preparations have gained wide acclaim among anesthesiologists and resuscitators, namely: Reamberin, infusion solution — a ...
S. V. Sviridov +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Comparison of Comorbidities in Relation to Critical Conditions among Coronavirus Disease 2019 Patients: A Network Meta-Analysis. [PDF]
Infect Chemother, 2021 Hoang T, Tran Thi Anh T.
europepmc +1 more source
Critical fire weather conditions in southwest and plains: part 2
, 2014 This image is a reference map, where red dots indicate the locations of major wildfires on April 7, 2011, throughout the Southwest and Plains in the U.S., and in the Mexican states of Chihuahua and CoahuilaEducação Superior::Ciências Exatas e da Terra ...
National Oceanic and Atmospheric Administration
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Dyschloremia in Critically Ill Children as a Risk Factor for an Unfavorable Disease Outcome
Инновационная медицина КубаниBackground: Dyschloremia is a common electrolyte imbalance that exacerbates many critical conditions in children.Objective: To analyze etiology and pathogenic mechanisms of dyschloremia, its impact on an outcome of pediatric critical conditions based on ...
Yu. V. Bykov +6 more
doaj +1 more source