Results 121 to 130 of about 3,145,854 (263)

Success of Succinates and Prospects for Their Use in Critical Conditions

Антибиотики и Химиотерапия
To date, preparations containing succinic acid (succinate) are widely known to specialists working in intensive care. Several such preparations have gained wide acclaim among anesthesiologists and resuscitators, namely: Reamberin, infusion solution — a ...
S. V. Sviridov, A. V. Butrov, V. V. Afanasyev, Yu. P. Orlov, A. Yu. Petrov   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Comparison of Comorbidities in Relation to Critical Conditions among Coronavirus Disease 2019 Patients: A Network Meta-Analysis. [PDF]

Infect Chemother, 2021
Hoang T, Tran Thi Anh T.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dyschloremia in Critically Ill Children as a Risk Factor for an Unfavorable Disease Outcome

Инновационная медицина Кубани
Background: Dyschloremia is a common electrolyte imbalance that exacerbates many critical conditions in children.Objective: To analyze etiology and pathogenic mechanisms of dyschloremia, its impact on an outcome of pediatric critical conditions based on ...
Yu. V. Bykov, A. N. Obedin, A. A. Muravyova, O. V. Zinchenko, V. V. Fisher, I. V. Yatsuk, E. V. Volkov   +6 more
doaj   +1 more source

Diagnostics in critical conditions [PDF]

Саратовский научно-медицинский журнал, 2011
The purpose of research: improvement of quality of diagnostics at the patients in a critical condition in intensive care unit. Material and methods. In total have analyzed 1957 medical cards of the patients who have died in ICU»s.
SadchikovD.V., PrigorodovM.V., IvanovR.V.   +2 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Safety culture in Australian intensive care units: Establishing a baseline for quality improvement

, 2013
Background: Workplace safety culture is a crucial ingredient in patients' outcomes and is increasingly being explored as a guide for quality improvement efforts.
Chamberlain, D, Hewson-Conroy, Karena, Chaboyer, W, Chamberlain, Di, Thalib, Lukman, Longbottom, Paula, Thalib, L, Grealy, Bernadette, Elderkin, Tania, McCutcheon, C, Elderkin, T, Longbottom, P, McCutcheon, Catherine, Brittin, M, Hewson-Conroy, Kareena, Hewson-Conroy, K, Brittin, Maureen, Chaboyer, Wendy, Grealy, B   +18 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source