Results 181 to 190 of about 17,623,491 (284)

Fostering Critical Consciousness Through Theater of the Oppressed: A Mixed-Methods Study With Gay, Bisexual, Queer, and Transgender Men in Singapore. [PDF]

J Community Psychol
Puvaneyshwaran D, Low AJ, Chong SY, Wee YX, Lee J, Liang P.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Pulsed field ablation vs. thermal ablation for pulmonary vein isolation: a network meta-analysis of randomized controlled trials. [PDF]

Europace
Latini AC, Penna M, Saglietto A, Landra F, Chiarito M, Villaschi A, Filiberti G, Carli S, Valcher S, Valeriano C, Amata F, Sanniti A, Panico C, Figliozzi S, Tritto MV, Condorelli G, Penela D.   +16 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Isotretinoin and serum thyroid parameters: systematic review and meta-analysis. [PDF]

An Bras Dermatol
Mostafa N, Hong E, Stewart T.
europepmc   +1 more source

Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data

International Journal of Evidence-Based Healthcare, 2015
Z. Munn, Sandeep Moola, K. Lisy, Dagmara Riitano, C. Tufanaru   +4 more
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Nutrition as the Foundation of Human Capital: Pathways to Holistic Development. [PDF]

Matern Child Nutr
Hassen DM.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Impact of indoor exposure to particulate matter on the progression of idiopathic pulmonary fibrosis: a prospective multicentre cohort study protocol. [PDF]

BMJ Open Respir Res
Yoon HY, Oh JH, Choi WI, Choi SM, Park J, Jo YS, Park SW, Lee JH, Lee HK, Kim SY, Woo A, Kim YH, Yoo H, Park JS, Kang HK, Kang JE, Park JH, Kim WJ, Kim KN, Song JW.   +19 more
europepmc   +1 more source