Results 201 to 210 of about 17,623,491 (284)

The double helix of data extraction:radicalising reflexivity in critical data studies

The increasing value of data is rendering data extraction ubiquitous. Looking at recent research, I argue that work critical of extractive dynamics can give rise to a ‘double-helix of data extraction’ that exacerbates existing asymmetries by appropriating the means of critique of affected populations.
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effectiveness of physical therapy techniques and methods in the management of endometriosis symptoms: A systematic review with meta-analysis. [PDF]

Braz J Phys Ther
Mena-González A, Leirós-Rodríguez R, Hernandez-Lucas P.   +2 more
europepmc   +1 more source

Cosmopolitan Critical Data Studies

openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Differential treatment effects across subgroups in immunomodulatory drugs for sepsis: protocol for a systematic review. [PDF]

BMJ Open
Ding L, Bai C, Jian L, Hu D, Xiong J, Zhang Z, He Q, Wang Y, Xu J, Ge L, Wang W, Sun X.   +11 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Shift Transition Communication Among Nurses: A Systematic Review of ISBAR and SBAR-Based Structured Handover Tools. [PDF]

Nurs Open
Rasiya A, Raheem UA.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Effects of expiratory muscle strength training on swallowing in survivors of critical illness: A systematic review and narrative synthesis. [PDF]

J Intensive Care Soc
Skurok P, Johnston BW, Brown E, Timothy C, Morse C, Turton P.   +5 more
europepmc   +1 more source