Results 41 to 50 of about 153,479 (218)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Advanced Analytical Modeling of Polytropic Gas Flow in Pipelines: Unifying Flow Regimes for Efficient Energy Transport

Technologies
In the present work, a new analytical model of polytropic flow in constant-diameter pipelines is developed to accurately describe the flow of compressible gases, including natural gas and hydrogen, explicitly accounting for heat exchange between the ...
Laszlo Garbai, Robert Santa, Mladen Bošnjaković   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Numerical Study of Heat Transfer Performance of Molten Salt-Based Nanofluid in the Novel Twisted Cloverleaf U-Tube

Engineering
Molten salt is widely adopted in diverse thermal energy storage systems owing to its exceptional thermodynamic properties and economical cost.
Yifan Gui, Yuanqiang Duan, Shuo Zhang, Yu Huang, Minmin Zhou, Lunbo Duan   +5 more
doaj   +1 more source

Heat Transfer Characteristics during Boiling of Immiscible Liquids Flowing in Narrow Rectangular Heated Channels

Frontiers in Mechanical Engineering, 2017
The use of immiscible liquids for cooling of surfaces with high heat generation density is proposed based on the experimental verification of its superior cooling characteristics in fundamental systems of pool boiling and flow boiling in a tube.
Yasuhisa Shinmoto, Daijiro Yamamoto, Daisuke Fujii, Haruhiko Ohta   +3 more
doaj   +1 more source

The influence of bubble departure characteristics on CHF prediction at high-pressure conditions

Case Studies in Thermal Engineering, 2020
The two-fluid Eulerian model, coupled with the heat flux partitioning model, is being widely used to predict subcooled flow boiling characteristics and critical heat flux (CHF).
Sai Raja Gopal Vadlamudi, Arun K. Nayak
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Relationship between heat flux and bubble population density in heat transfer enhancement of flow boiling using microstructured surfaces

Journal of Thermal Science and Technology
Recently, the thermal management of electronic devices has become paramount because the power density of semiconductor elements is rapidly increasing with the rapid miniaturisation of electronic devices.
Akira Sukma Prawira GREGORIUS, Shunsuke SASAKI, Shuhei HAYASHI, Tatsuhiko AIZAWA, Naoki ONO   +4 more
doaj   +1 more source