Results 161 to 170 of about 2,758,203 (294)

Critical Design Parameters of Tantalum-Based Comb Structures to Manipulate Mammalian Cell Morphology. [PDF]

Materials (Basel)
Moussa HI, Logan M, Eskandari A, Glerum DM, Aucoin MG, Tsui TY.   +5 more
europepmc   +1 more source

Critical design aspects involved in the study of Paneth cells and the intestinal microbiota. [PDF]

Gut Microbes, 2014
Shanahan MT, Carroll IM, Gulati AS.
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Critical Design and Characterization Methodology for a Homemade Three-Axis Fluxgate Magnetometer Measuring Ultra-Low Magnetic Fields. [PDF]

Sensors (Basel)
Can H, Kutlu FNÇ, Svec P, Skorvanek I, Sözeri H, Doğan Ç, Topal U.   +6 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Critical Design Considerations for Longer-Term Wear and Comfort of On-Body Medical Devices. [PDF]

Bioengineering (Basel)
Stuart S, de Kok M, O'Searcoid B, Morrisroe H, Serban IB, Jagers F, Dulos R, Houben S, van de Peppel L, van den Brand J.   +9 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Critical design decisions and user demographics in enhancing real-time digital mental health interventions: A systematic review. [PDF]

Digit Health
Fouyaxis J, Bidargaddi N, Du W, Looi JCL, Lipschitz J.   +4 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source