Results 171 to 180 of about 2,209,767 (280)

Critical actions for embedding research evidence into practice: how to get the most out of your implementation scientist. [PDF]

JBI Evid Implement
Mazariego C, Gul H, Liang S, Kelly-Hanku A, Brady B, Allida S, Baffsky R, McErlean G, Crespo C, Hodgins M, Christie L, Peiris D, Debono D, MacMillan F, Ferguson C, Heneka N, Kennedy SG, Liu H, Morrow A, Fontaine G, Findlay M, Middleton S, Lim D, Straiton N, Taylor N.   +24 more
europepmc   +1 more source

Critical Design Review

Critical Design ReviewDRL list of Project Management Plan for CDR•Weight analysis•Outline Drawings•Electrical power consumption characteristics•Bonding and grounding diagram•Drawing tree•Part List•Detailed Design Files•Logistic Analysis(MTBF / MTTR, Replaceable units)•Product Acceptance Test Procedure (PTP): for testing of series products•STTE design ...
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

An Invariant-Based Constitutive Model for Composite Laminates. [PDF]

Materials (Basel)
Liu W, Fan S, Mu X, Ma R, Wang X.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A validated workflow for the design and certification of below-the-hook lifting devices integrating finite element analysis and physical proof testing. [PDF]

Sci Rep
Habib ES, Shamso E.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploring neurology resident experiences with a no-prep journal club to learn research study design and critical appraisal. [PDF]

BMC Med Educ
Fu KA, Elting S, Chan JM, Strowd RE.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Experimental study on strengthening interior beam column joints in reinforced concrete structures using wing walls. [PDF]

Sci Rep
Yuebing L, Qi Y, Hang W, Xitian H, Shuang X.   +4 more
europepmc   +1 more source